Age- and sex-associated trends in bloodstream infection - A population-based study in Olmsted County, Minnesota
Age- and sex-associated trends in bloodstream infection - A population-based study in Olmsted County, Minnesota
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DOI：
10.1001/archinte.167.8.834
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发表时间：
2007-04-23
影响因子：
--
通讯作者：
Baddour, Larry M.
中科院分区：
文献类型：
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作者：
Uslan, Daniel Z.;Crane, Sarah J.;Baddour, Larry M.
背景：尽管人们越来越关注血液培养分离株的抗菌素耐药性和新出现的病原体，但当前基于人群的年龄和性别特异性血流感染（bsi）发生率数据有限。方法：对2003年1月1日至2005年12月31日期间明尼苏达州奥姆斯特德县所有具有BSI的居民进行回顾性、基于人群的队列研究。使用罗切斯特流行病学项目的医疗记录链接系统和微生物记录来确定事件病例。结果：共鉴定出血培养结果阳性的独特患者1051例；401个（38.2%）为污染。在650例具有临床相关性培养的患者中，平均+/-SD年龄为63.1+/-23.1岁，其中52.5%为男性。最常见的细菌是大肠杆菌（163例bsi患者[25.1%]）和金黄色葡萄球菌（108例bsi患者[16.6%]）。院内性脑梗死男性比女性更常见（23.8% vs 13.9%； P= 0.002）。经年龄调整后的BSI发病率为女性每10万人年156例，男性每10万人年237例
Background: Despite increasing concerns about antimicrobial resistance and emerging pathogens among blood culture isolates, contemporary population-based data on the age- and sex-specific incidence of bloodstream infections (BSIs) are limited.Methods: Retrospective, population-based, cohort study of all residents of Olmsted County, Minnesota, with a BSI between January 1, 2003, and December 31, 2005. The medical record linkage system of the Rochester Epidemiology Project and microbiology records were used to identify incident cases.Results: A total of 1051 unique patients with positive blood culture results were identified; 401 (38.2%) were classified as contaminated. Of 650 patients with cultures deemed clinically relevant, the mean+/-SD age was 63.1+/-23.1 years, and 52.5% were male. The most common organisms identified were Escherichia coli (in 163 patients with BSIs [25.1%]) and Staphylococcus aureus (in 108 patients with BSIs [16.6%]). Nosocomial BSIs were more common in males than females (23.8% vs 13.9%; P=.002). The age-adjusted incidence rate of BSI was 156 per 100 000 person-years for females and 237 per 100 000 person-years for males (P