Predictive value of the seventh edition American Joint Committee on Cancer staging system for conjunctival melanoma.
Predictive value of the seventh edition American Joint Committee on Cancer staging system for conjunctival melanoma.
复制标题
第七版美国癌症联合委员会分期系统对结膜黑色素瘤的预测价值。
DOI：
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
P. Finger
中科院分区：
文献类型：
--
作者：
Y. Yousef;P. Finger
客观化
评价第七版美国癌症联合委员会(AJCC)结膜黑色素瘤分期系统对结膜黑色素瘤的预测价值。
方法
通过回顾病历、病理报告和彩色照片，对42例42眼结膜黑色素瘤患者进行了回顾性、观察性病例系列研究。主要评估结果为人口学资料、偏侧性、肿瘤大小、厚度、病理诊断、第七版AJCC分期(临床和病理)、复发、转移和随访时间。
结果
没有性别偏好，年龄中位数为61岁。复发率为33%(14/42)，其中%的患者初治后中位时间为2.5年(1~5年)。19%的患者发现有转移。肿瘤累及1象限以上(P=0.02)、肿瘤厚度大于0.5 mm(P=0.04)、肿瘤多灶性(P=0.04)是肿瘤复发的显著预测因素。肿瘤厚度大于0.5 mm(P=.005)、肿瘤侵袭性(P=.04)、病理诊断为结膜黑色素瘤而非原位黑色素瘤(P=.04)和肿瘤复发(P<；.001)是肿瘤转移高危因素。同样，AJCC T分期的增加(临床和病理)与不良预后相关。例如，与临床分期相关的复发率分别为19%(Tis)、27%(T1)、33%(T2)和75%(T3)。临床分期相关淋巴和远处转移率分别为0%(Tis)、20%(T1)、0%(T2)和63%(T3)。
结论
晚期AJCC T期肿瘤(临床和病理)复发和转移的风险较高。在这项研究中，第七版AJCC分期系统预测了结膜黑色素瘤的局部控制和全身扩散。
OBJECTIVE
To evaluate the predictive value of the seventh edition American Joint Committee on Cancer (AJCC) staging system for conjunctival melanoma.
METHODS
Retrospective, observational case series of 42 eyes of 42 patients with conjunctival melanoma studied by reviewing medical records, pathology reports, and color photographs. The main evaluated outcomes were demographic information, laterality, tumor size, thickness, pathologic diagnosis, seventh edition AJCC stage (clinical and pathologic), recurrence, metastasis, and duration of follow-up.
RESULTS
There was no sex preference, and the median age was 61 years. Recurrent disease was noted in 33% of patients (n = 14 of 42), with 64% occurring at a median of 2.5 years (range, 1-5 years) after primary treatment. Metastasis was noted in 19% of patients. The significant predictive factors for high risk of tumor recurrence were tumors involving more than 1 quadrant (P = .02), tumors thicker than 0.5 mm (P = .04), and tumor multifocality (P = .04). The significant predictive factors for high risk of tumor metastasis were tumors thicker than 0.5 mm (P = .005), tumor invasiveness (P = .04), pathologic diagnosis of conjunctival melanoma rather than melanoma in situ (P = .04), and tumor recurrence (P < .001). Similarly, increasing AJCC T stages (clinical and pathologic) were associated with unfavorable outcomes. For example, clinical stage-related recurrence rates were 19% (Tis), 27% (T1), 33% (T2), and 75% (T3). Clinical stage-related lymphatic and distant metastasis rates were 0% (Tis), 20% (T1), 0% (T2), and 63% (T3).
CONCLUSIONS
Advanced AJCC T-stage (clinical and pathologic) tumors were at higher risk for recurrence and metastasis. In this study, the seventh edition AJCC staging system was predictive of local control and systemic spread of conjunctival melanoma.
原发性获得性结膜黑变病。
影响因子：
3.3
作者：
Folberg,R;McLean,IW;Zimmerman,LE
通讯作者：
Zimmerman,LE