Frontostriatal abnormalities in adolescents with bipolar disorder: Preliminary observations from functional MRI
Frontostriatal abnormalities in adolescents with bipolar disorder: Preliminary observations from functional MRI
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DOI：
10.1176/appi.ajp.160.7.1345
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发表时间：
2003-07-01
影响因子：
17.7
通讯作者：
Peterson, BS
中科院分区：
文献类型：
--
作者：
Blumberg, HP;Martin, A;Peterson, BS
目的：本研究调查了成人双相情感障碍中观察到的前额叶系统功能异常是否在患有该疾病的青少年中表现出来。方法：10 名双相情感障碍青少年和 10 名健康对照受试者在事件相关功能磁共振成像期间参与颜色命名斯特鲁普任务。结果：双相情感障碍组左侧壳核和丘脑的信号增加显着大于健康组。在健康组中，年龄与双侧腹侧前额皮质和纹状体的信号增加呈正相关，但在双相情感障碍组中则不然。在双相情感障碍受试者中，抑郁症状与腹侧纹状体信号增加呈正相关。结论：这些发现表明双相情感障碍青少年的额纹状体回路的皮质下部分存在功能障碍。之前在成年人中观察到的前额叶异常的缺失以及在正常对照受试者中观察到的前额叶活动的与年龄相关的增加的缺失表明，双相情感障碍在青春期过程中可能会出现前额叶功能的发育障碍。
Objective: This study investigated whether the functional abnormalities in prefrontal systems observed in adult bipolar disorder are manifested in adolescents with this illness.Method: Ten adolescents with bipolar disorder and 10 healthy comparison subjects participated in a color-naming Stroop task during event-related functional magnetic resonance imaging.Results: Signal increases in the left putamen and thalamus were significantly greater in the bipolar disorder group than in the healthy group. Age correlated positively with signal increases in the bilateral rostroventral prefrontal cortex and the striatum in the healthy group but not in the bipolar disorder group. In the bipolar disorder subjects, depressive symptoms correlated positively with signal increases in the ventral striatum.Conclusions: These findings suggest the presence of dysfunction in the subcortical portions of the frontostriatal circuits in adolescents with bipolar disorder. The absence of the prefrontal abnormalities that were observed previously in adults and the absence of the age-related increases in prefrontal activity observed in normal comparison subjects suggest that a developmental disturbance in prefrontal function may emerge in bipolar disorder over the course of adolescence.