A 90 days oral toxicity of imidacloprid in female rats: Morphological, biochemical and histopathological evaluations
A 90 days oral toxicity of imidacloprid in female rats: Morphological, biochemical and histopathological evaluations
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DOI：
10.1016/j.fct.2010.02.009
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发表时间：
2010-05-01
影响因子：
4.3
通讯作者：
Srivastava, L. P.
中科院分区：
文献类型：
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作者：
Bhardwaj, Shipra;Srivastava, M. K.;Srivastava, L. P.
以吡虫啉0、5、10、20 mg/(kg·d)剂量对雌性大鼠进行90d经口毒性试验。在20 mg/kg/d剂量下，体重增加明显减少，尸检时，肝、肾和肾上腺的相对体重也显著增加。治疗期间未发生死亡，高剂量组进食量减少。在临床生化指标中，大剂量吡虫啉可引起血清GOT、GFT、血糖和BUN显著升高，血清和脑组织AChE活性降低。在最高剂量暴露时，小鼠的自发活动也降低，但血液学和尿液参数无明显变化。大剂量吡虫啉染毒后，大鼠脑、肝、肾均出现轻度病变。根据形态、生化、血液学和神经病理学研究，吡虫啉在5 mg/kg/d和10 mg/kg/d剂量对雌性大鼠无明显影响，但在20 mg/kg/d剂量下对雌性大鼠有明显的毒理作用。因此，10 mg/kg/d剂量可被认为是雌性大鼠的无观察效应水平(NOEL)。(C)2010爱思唯尔有限公司。保留所有权利。
A 90 days oral toxicity study of imidacloprid was conducted in female rats with doses of 0, 5, 10, 20 mg/kg/day. Decrease in the body weight gain was observed at 20 mg/kg/day and at necropsy the relative body weights of liver, kidney and adrenal was also significantly increased at this dose level. No mortality occurred during treatment period while food intake was reduced at high dose level. In clinical chemistry parameters high dose of imidacloprid has caused significant elevation of serum GOT, GFT, glucose and BUN and decreased the activity of AChE in serum and brain. The spontaneous locomotor activity was also decreased at highest dose exposure where as there were no significant changes in hematological and urine parameters. The brain, liver and kidney of rats exposed with high dose of imidacloprid had showed mild pathological changes. Based on the morphological, biochemical, hematological and neuropathological studies it is evident that imidacloprid has not produced any significant effects at 5 and 10 mg/kg/day doses but induced toxicological effects at 20 mg/kg/day to female rats. Hence, 10 mg/kg/day dose may be considered as no observed effect level (NOEL) for female rats. (C) 2010 Elsevier Ltd. All rights reserved.