The expression of myeloid antigens CD13 and/or CD33 is a marker of ALK plus anaplastic large cell lymphomas
The expression of myeloid antigens CD13 and/or CD33 is a marker of ALK plus anaplastic large cell lymphomas
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DOI：
10.1309/pln1na4qb2pc1cmq
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发表时间：
2008-10-01
影响因子：
3.5
通讯作者：
Allan, Robert W.
中科院分区：
文献类型：
--
作者：
Bovio, Ian M.;Allan, Robert W.
我们通过流式细胞术回顾性研究了 20 例间变性大细胞淋巴瘤 (ALCL)（9 例间变性淋巴瘤激酶 [ALK]+ 和 11 例 ALK-）的免疫表型，特别强调骨髓相关抗原 CD13 和/或 CD33 的异常表达。所有 ALCL 均表达 CD45、HLA-DR 和 CD30。大多数 (8/9) ALK+ ALCS 表达至少 1 种表面 T 细胞抗原（CD4，6/9 [67%]；CD7，6/9 [67%]；CD2，5/9 [56%]；CD5，2/9 [22%]；CD8，2/9 [22%]；CD3，1/9 [11%]）。所有 ALK-ALCL 均表达至少 1 种表面 T 细胞抗原（CD3，7/11 [64%]；CD4，6/11 [55%]；Cd2，6/11 [55%]；CD7，2/11 [18%]；CD5，1/11 [9%]；CD8，1/11 [9%]）。 Cd13 和/或 CD33 在所有 (9/9) ALK+ ALCL 中表达，而 11 个 ALK-ALCL 中有 1 个表达 (9%) (P < .001)。与 ALK+ ALCL (1/9) 相比，表面 CD3 更有可能在 ALK-ALCL (7/11) 中表达 (P = .03)。骨髓相关抗原 CD13 和/或 CD33 是 ALK+ ALCL 的敏感标记，但并非完全特异性标记，不应被误解为指示骨髓肉瘤。
We retrospectively studied the immunophenotype by flow cytometry of 20 anaplastic large cell lymphomas (ALCLs) (9 anaplastic lymphoma kinase [ALK]+ and 11 ALK-) with a particular emphasis on the aberrant expression of the myeloid associated antigens CD13 and/or CD33. All ALCLs expressed CD45, HLA-DR, and CD30. Most (8/9) ALK+ ALCLS expressed at least 1 surface T-cell antigen (CD4, 6/9 [67%]; CD7, 6/9 [67%]; CD2, 5/9 [56%]; CD5, 2/9 [22%]; CD8, 2/9 [22%]; CD3, 1/9 [11%]). All ALK-ALCLs expressed at least 1 surface T-cell antigen (CD3, 7/11 [64%]; CD4, 6/11 [55%]; Cd2, 6/11 [55%]; CD7, 2/11 [18%]; CD5, 1/11 [9%]; CD8, 1/11 [9%]). Cd13 and/or CD33 were expressed in all (9/9) ALK+ ALCLs compared with 1 of 11 ALK-ALCLs (9%) (P < .001). Surface CD3 was more likely expressed in ALK-ALCLs (7/11) compared with ALK+ ALCLs (1/9) (P = .03). The myeloid-associated antigens CD13 and/or CD33 are sensitive but not entirely specific markers of ALK+ ALCLs and should not be misinterpreted as indicating myeloid sarcoma.