Toxicology and pharmacokinetics of 1-methyl-D-tryptophan: Absence of toxicity due to saturating absorption
Toxicology and pharmacokinetics of 1-methyl-D-tryptophan: Absence of toxicity due to saturating absorption
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DOI：
10.1016/j.fct.2007.07.017
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发表时间：
2008-01-01
影响因子：
4.3
通讯作者：
Munn, David H.
中科院分区：
文献类型：
--
作者：
Jia, Lee;Schweikart, Karen;Munn, David H.
1-甲基-D-色氨酸（D-1 MT）逆转吲哚胺2，3-双加氧酶（IDO）的免疫抑制作用，目前正在开发作为疫苗佐剂和与化疗联合使用的免疫抑制剂。本研究检查了D-1 MT的药代动力学和毒性，为临床试验做准备。D-1 MT在大鼠血浆中孵育24 h未产生显著降解，
1-methyl-D-tryptophan (D-1MT) reverses the immunosuppressive effect of indoleamine 2,3-dioxygenase (IDO), and it is currently being developed both as a vaccine adjuvant and as an immunotherapeutic agent for combination with chemotherapy. The present study examined the pharmacokinetics and toxicity of D-1MT in preparation for clinical trials. Incubation of D-1MT in rat plasma for 24 h produced no significant degradation, with