Decarbonylative Synthesis of Aryl Nitriles from Aromatic Esters and Organocyanides by a Nickel Catalyst
Decarbonylative Synthesis of Aryl Nitriles from Aromatic Esters and Organocyanides by a Nickel Catalyst
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DOI：
10.1055/s-0040-1705943
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发表时间：
2020-10
期刊：
影响因子：
2
通讯作者：
Junichiro Yamaguchi;Keiichiro Iizumi;M. Kurosawa;Ryota Isshiki;K. Muto
中科院分区：
文献类型：
--
作者：
Junichiro Yamaguchi;Keiichiro Iizumi;M. Kurosawa;Ryota Isshiki;K. Muto
摘要研究了在镍催化剂存在下芳香酯与氨基乙腈的脱羰氰化反应。该反应的关键是使用基于噻吩的双膦配体dcypt，允许在不产生化学计量的含金属或卤素的化学废物的情况下合成芳基腈。广泛的芳族酯，包括杂烯和药物分子，可以转化为芳基腈。
Abstract A decarbonylative cyanation of aromatic esters with aminoacetonitriles in the presence of a nickel catalyst was developed. The key to this reaction was the use of a thiophene-based diphosphine ligand, dcypt, permitting the synthesis of aryl nitrile without the generation of stoichiometric metal- or halogen-containing chemical wastes. A wide range of aromatic esters, including hetarenes and pharmaceutical molecules, can be converted into aryl nitriles.