EARLY PATHOGENESIS OF INFECTION IN THE LIVER WITH THE FACULTATIVE INTRACELLULAR BACTERIA LISTERIA-MONOCYTOGENES, FRANCISELLA-TULARENSIS, AND SALMONELLA-TYPHIMURIUM INVOLVES LYSIS OF INFECTED HEPATOCYTES BY LEUKOCYTES
EARLY PATHOGENESIS OF INFECTION IN THE LIVER WITH THE FACULTATIVE INTRACELLULAR BACTERIA LISTERIA-MONOCYTOGENES, FRANCISELLA-TULARENSIS, AND SALMONELLA-TYPHIMURIUM INVOLVES LYSIS OF INFECTED HEPATOCYTES BY LEUKOCYTES
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DOI：
10.1128/iai.60.12.5164-5171.1992
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发表时间：
1992-12-01
影响因子：
3.1
通讯作者：
NORTH, RJ
中科院分区：
文献类型：
--
作者：
CONLAN, JW;NORTH, RJ
结果表明，单核细胞增生李斯特菌，土拉热弗朗西斯菌，鼠伤寒沙门氏菌是兼性细胞内细菌的能力，侵入和生长在体内的非吞噬细胞。在肝脏中，观察到所有这些病原体侵入肝细胞并在肝细胞中广泛繁殖。在所有三种情况下，炎性吞噬细胞迅速聚集到感染灶，在那里它们似乎引起感染肝细胞的破坏，从而将细菌释放到细胞外空间，在那里它们可能被吞噬细胞摄取和破坏。如果通过用针对骨髓单核细胞的3型补体受体的单克隆抗体（NIMP-R10）治疗小鼠来防止吞噬细胞在肝脏感染病灶处积聚，则肝细胞裂解不能发生，并且细菌在其中不受限制地增殖。在这种情况下，亚致死性感染会迅速致命。这些研究结果强烈表明，感染的肝细胞的吞噬细胞裂解是一个重要的一般早期防御策略，对肝脏感染至少有三种不同的细胞内细菌。
The results show that Listeria monocytogenes, Francisella tularensis, and Salmonella typhimurium are facultative intracellular bacteria with a capacity to invade and grow in nonphagocytic cells in vivo. In the liver, all of these pathogens were seen to invade and to multiply extensively in hepatocytes. In all three cases, inflammatory phagocytes were rapidly marshalled to foci of infection where they appeared to cause the destruction of infected hepatocytes, thereby releasing bacteria into the extracellular space, in which presumably they could be ingested and destroyed by the phagocytes. If phagocytic cells were prevented from accumulating at foci of liver infection by treatment of the mice with a monoclonal antibody (NIMP-R10) directed against the type 3 complement receptor of myelomonocytic cells, then lysis of hepatocytes failed to occur and bacteria proliferated unrestrictedly within them. Under these circumstances, otherwise sublethal infections became rapidly lethal. These findings strongly suggest that lysis of infected hepatocytes by phagocytic cells is an important general early-defense strategy against liver infection with at least three different intracellular bacteria.