Effect of fenugreek (Trigonella foenum-graecum L) seeds on serum parameters in normal and streptozotocin-induced diabetic rats
Effect of fenugreek (Trigonella foenum-graecum L) seeds on serum parameters in normal and streptozotocin-induced diabetic rats
复制标题
DOI：
10.1016/j.nutres.2007.09.006
复制
发表时间：
2007-11-01
影响因子：
4.5
通讯作者：
Sokhteh, Mousa
中科院分区：
文献类型：
--
作者：
Eidi, Akram;Eidi, Maryam;Sokhteh, Mousa
许多草药已被推荐用于治疗糖尿病。采用正常大鼠和链脲佐菌素诱导的糖尿病大鼠，观察胡芦巴醇提物的降糖作用。在正常和链脲佐菌素诱导的糖尿病大鼠中，评价了连续14天经口给予Femagreek提取物（0.1、0.25和0.5g/kg体重）对血清葡萄糖、总胆固醇、三酰甘油、尿素、尿酸、肌酐、天冬氨酸氨基转移酶（AST）和丙氨酸氨基转移酶（ALT）水平的影响。治疗胡芦巴提取物减轻糖尿病大鼠体重减轻。给药的提取物显着降低血清葡萄糖，总胆固醇，甘油三酯，尿素，尿酸，肌酐，AST和ALT水平，而它增加了糖尿病大鼠的血清胰岛素，但在正常大鼠中没有（P <0.05）。对胡芦巴提取物和已知的抗糖尿病药物格列本脲（600 μ g/kg）的作用进行了比较。提取物的抗糖尿病作用与格列本脲相似。结论是该植物应被认为是一个很好的候选人，为未来的研究糖尿病。(c)2007爱思唯尔公司All rights reserved.
Many herbal medicines have been recommended for the treatment of diabetes. The antidiabetic effect of fenugreek ethanolic extract (Trigonella foenum-graecum L) was investigated in normal and streptozotocin-induced diabetic rats. Oral administration of femagreek extract (0.1, 0.25, and 0.5 g/kg body weight) for 14 days on the level of serum glucose, total cholesterol, triacylglycerol, urea, uric acid, creatinine, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in normal and streptozotocin-induced diabetic rats were evaluated. Treatment of fenugreek extract alleviated body weight loss in diabetic rats. Administrations of the extract significantly decreased serum glucose, total cholesterol, triacylglycerol, urea, uric acid, creatinine, AST, and ALT levels, whereas it increased serum insulin in diabetic rats but not in normal rats (P < .05). A comparison was made between the action of fenugreek extract and glibenclamide (600 mu g/kg), the known antidiabetic drug. The antidiabetic effect of the extract was similar to that observed for glibenclamide. It is concluded that the plant should be considered as an excellent candidate for future studies on diabetes mellitus. (c) 2007 Elsevier Inc. All rights reserved.