The effects of two non-steroidal anti-inflammatory drugs on the mobility of laying hens with keel bone fractures
The effects of two non-steroidal anti-inflammatory drugs on the mobility of laying hens with keel bone fractures
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DOI：
10.1111/vaa.12175
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发表时间：
2015-03-01
影响因子：
1.7
通讯作者：
Murrell, Joanna C.
中科院分区：
文献类型：
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作者：
Nasr, Mohammed A. F.;Nicol, Christine J.;Murrell, Joanna C.
研究美洛昔康和卡洛芬给药对有和没有龙骨骨折的母鸡活动性的影响。研究设计在两个实验中的每一个实验中，采用盲法随机交叉设计，方法第一组（n=63）用卡洛芬25 mg/kg（-1）处理有和无龙骨骨折的Lohman Brown母鸡，和生理盐水皮下注射两次第二组（n=40）皮下注射美洛昔康（5 mg/kg）和生理盐水。在每次处理后，测量鸟从离地面50、100和150 cm的栖木飞下来的潜伏期。从实验1和2的数据分别进行了分析，药物治疗的效果与盐水相比，对鸟类的着陆时间与龙骨骨折进行了评估，使用MLwiN.ResultsIn两个实验潜伏期从栖息地飞下来的时间较长，在母鸡龙骨骨折和有一个显着的相互作用栖息高度和骨折状态。对于卡洛芬，在50 cm、100 cm和150 cm栖木高度处，发生骨折的鸟分别需要（平均SD）2.5 +/- 2.9、6.8 +/- 9.7和11.5 +/-13.2秒飞下，而无骨折的鸟分别需要1.3 +/- 0.5、2.3 +/- 1.2和4.2 +/-3.1秒。对于美洛昔康，在50 cm、100 cm和150 cm的栖息高度，有骨折的鸟分别需要2.9 +/- 2.5、49.8 +/- 85.4和100.3 +/-123.6秒，而没有骨折的鸟分别需要0.7 +/- 0.5、2.5 +/- 7.1和3.0 +/-4.6秒才能飞下来。卡洛芬或美洛昔康treatment.Conclusion和clinical relevanceThese数据提供了进一步的证实，龙骨骨折减少鸟类从栖息地移动的意愿。
ObjectiveInvestigate the effects of administration of meloxicam and carprofen on the mobility of hens with and without keel fractures.Study designWithin each of two experiments a blinded' randomised cross over design whereby birds received either the test drug (carprofen or meloxicam) or saline.AnimalsTwo groups of Lohman Brown hens with and without keel bone fractures.MethodsThe first group (n=63) was treated with carprofen 25mgkg(-1) and saline subcutaneously, twice. The second group (n=40) was treated with meloxicam (5mgkg(-1)) and saline subcutaneously. The latency of birds to fly down from perches 50, 100 and 150cm above the ground was measured after each treatment. Data from experiment 1 and 2 were analysed separately; the effects of drug treatment compared with saline on landing time for birds with and without keel bone fractures were evaluated using MLwiN.ResultsIn both experiments latency to fly down from perches was longer in hens with keel fractures and there was a significant interaction between perch height and fracture status. For carprofen, at the 50cm, 100cm and 150cm perch heights, birds with fractures took (meanSD) 2.5 +/- 2.9, 6.8 +/- 9.7 and 11.5 +/- 13.2seconds respectively to fly down compared with 1.3 +/- 0.5, 2.3 +/- 1.2 and 4.2 +/- 3.1seconds for birds without fractures. For meloxicam, at the 50cm, 100cm and 150cm perch heights, birds with fractures took 2.9 +/- 2.5, 49.8 +/- 85.4 and 100.3 +/- 123.6seconds respectively compared with 0.7 +/- 0.5, 2.5 +/- 7.1 and 3.0 +/- 4.6seconds to fly down for birds without fractures. There was no significant effect of carprofen or meloxicam treatment.Conclusion and clinical relevanceThese data provide further confirmation that keel fractures reduce the willingness of birds to move from perches.