Isolating the neural mechanisms of age-related changes in human working memory
Isolating the neural mechanisms of age-related changes in human working memory
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DOI：
10.1038/74889
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发表时间：
2000-05-01
影响因子：
25
通讯作者：
D'Esposito, M
中科院分区：
文献类型：
--
作者：
Rypma, B;D'Esposito, M
工作记忆（WM），信息编码到记忆中，积极维持和随后检索的过程，随着年龄的增长而下降。为了验证这一假设，即年龄相关的变化，在前额叶皮层（PFC）可能介导这种WM下降，我们使用功能性MRI调查年龄差异PFC活动在单独的WM任务组件（编码，维护，检索）。我们发现更大的PFC活动在年轻人比老年人只有背外侧PFC在记忆检索。快速年轻的受试者在检索过程中表现出较少的背外侧PFC激活比缓慢年轻的受试者，而老年人表现出相反的模式。因此，背外侧PFC的年龄相关变化，而不是腹外侧PFC的帐户与正常老化的WM下降。
Working memory (WM), the process by which information is coded into memory, actively maintained and subsequently retrieved, declines with age. To test the hypothesis that age-related changes in prefrontal cortex (PFC) may mediate this WM decline, we used functional MRI to investigate age differences in PFC activity during separate WM task components (encoding, maintenance, retrieval). We found greater PFC activity in younger than older adults only in dorsolateral PFC during memory retrieval. Fast younger subjects showed less dorsolateral PFC activation during retrieval than slow younger subjects, whereas older adults showed the opposite pattern. Thus age-related changes in dorsolateral PFC and not ventrolateral PFC account for WM decline with normal aging.