Chemoradiation: A new approach for the treatment of cervical cancer
Chemoradiation: A new approach for the treatment of cervical cancer
复制标题
放化疗：治疗宫颈癌的新方法
DOI：
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复制
发表时间：
2003
期刊：
影响因子：
--
通讯作者：
F. Cappuccini
中科院分区：
文献类型：
--
作者：
V. Loizzi;G. Cormio;G. Loverro;L. Selvaggi;P. Disaia;F. Cappuccini
尽管在筛查方面取得了进展，但宫颈癌仍然是世界范围内的一个主要健康问题。为了改善局部区域控制，新辅助治疗和放化疗都进行了试验。最近，由妇科肿瘤组、放射治疗肿瘤组和西南肿瘤组进行的五项随机临床试验表明，晚期宫颈癌放疗期间给予顺铂化疗在无进展生存期和总生存期方面具有显著优势。根据这些试验的结果，美国国家癌症研究所发布了一项临床公告，支持对高危早期和局部晚期宫颈癌同时使用顺铂化疗和放射治疗。随后，加拿大国家癌症研究所进行的另一项前瞻性随机试验未能显示局部晚期宫颈癌患者使用放化疗与单纯放疗相比的获益。本文将分析这六项临床试验，以确定放化疗在宫颈癌患者管理中的作用。此外，由于贫血是宫颈癌患者最有力的预后因素之一，我们建议评估血红蛋白水平降低与治疗结果之间的关系。
Despite advances in screening, cervical cancer remains a major health problem worldwide. In an effort to improve loco-regional control, both neoadjuvant and chemoradiation have been trialed. Recently, five randomized clinical trials performed by the Gynecologic Oncology Group, the Radiation Therapy Oncology Group and the Southwest Oncology Group have demonstrated a significant advantage both in progression-free and overall survival when cisplatin-based chemotherapy was administered during radiation for advanced stages of cervical cancer. Based on the results of these trials, the US National Cancer Institute released a Clinical Announcement supporting the concurrent use of cisplatin-based chemotherapy with radiation therapy for high-risk early stage and locally advanced stage cervical cancer. Subsequently, an additional prospective randomized trial performed by the National Cancer Institute of Canada was not able to show benefit with the use of chemoradiation compared with radiation alone for patients with locally advanced stage cervical cancer. This article will analyze these six clinical trials in order to determine the role of chemoradiation in the management of patients with cervical cancer. Furthermore, as anemia is one of the most powerful prognostic factors in patients with cervical cancer, we propose to evaluate the relationship between a decreased level of hemoglobin and treatment outcome.
DOI：
10.1097/00006254-200008000-00017
发表时间：
2000-04
期刊：
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
影响因子：
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作者：
W. Peters;P. Liu;R. Barrett;R. Stock;B. Monk;J. Berek;L. Souhami;P. Grigsby;W. Gordon;
通讯作者：
W. Peters;P. Liu;R. Barrett;R. Stock;B. Monk;J. Berek;L. Souhami;P. Grigsby;W. Gordon;
影响因子：
158.5
作者：
Keys, HM;Bundy, BN;Gersell, D
通讯作者：
Gersell, D
在 C3H/Km 小鼠模型系统中，分次照射加 c-DDP 和 5-FU 或加 c-DDP 和环磷酰胺的组合可带来依赖于时间安排的治疗效果。
DOI：
10.1016/0360-3016(91)90095-l
发表时间：
1991
期刊：
International journal of radiation oncology, biology, physics
影响因子：
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作者：
Kallman,RF;Rapacchietta,D;Zaghloul,MS
通讯作者：
Zaghloul,MS