Multiple Ebola virus transmission events and rapid decline of central African wildlife
Multiple Ebola virus transmission events and rapid decline of central African wildlife
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DOI：
10.1126/science.1092528
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发表时间：
2004-01-16
期刊：
影响因子：
56.9
通讯作者：
Rollin, PE
中科院分区：
文献类型：
--
作者：
Leroy, EM;Rouquet, P;Rollin, PE
过去四年来，加蓬和刚果共和国发生了多起人类和动物埃博拉疫情。人类爆发的疫情由不同病毒株引起的多种同时发生的流行病组成，每种流行病都是由处理不同的大猩猩、黑猩猩或小羚羊尸体引起的。在人类埃博拉疫情爆发期间，这些动物数量显着下降，这显然是埃博拉感染的结果。回收的尸体被多种埃博拉病毒株感染，这表明类人猿中埃博拉病毒的爆发是由自然宿主引入多种病毒造成的。对动物死亡率的监测可能有助于预测和预防人类埃博拉疫情的爆发。
Several human and animal Ebola outbreaks have occurred over the past 4 years in Gabon and the Republic of Congo. The human outbreaks consisted of multiple simultaneous epidemics caused by different viral strains, and each epidemic resulted from the handling of a distinct gorilla, chimpanzee, or duiker carcass. These animal populations declined markedly during human Ebola outbreaks, apparently as a result of Ebola infection. Recovered carcasses were infected by a variety of Ebola strains, suggesting that Ebola outbreaks in great apes result from multiple virus introductions from the natural host. Surveillance of animal mortality may help to predict and prevent human Ebola outbreaks.