Chronicles of the GTPase switch

Chronicles of the GTPase switch
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DOI:
10.1038/nchembio.608
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发表时间:
2011-08-01
影响因子:
14.8
通讯作者:
Zeghouf, Mahel
Zeghouf, Mahel
中科院分区:
生物学1区
文献类型:
--
作者:
Cherfils, Jacqueline;Zeghouf, Mahel

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GTP 酶开关是一种多功能分子装置,许多蛋白质(例如小 GTP 酶)都使用它来调节数量惊人的功能。尽管鸟嘌呤核苷酸循环的基础知识现已得到很好的确立,但下一个挑战是对这些蛋白质如何利用它来协调信号通路形成一个综合的看法。
The GTPase switch is a versatile molecular device used by many proteins, such as the small GTPases, to regulate an astounding number of functions. Although the basics of the guanine nucleotide cycle are now well established, the next challenge is to reach an integrated view of how these proteins use it to orchestrate signaling pathways.