EFFECT OF SKULL POROUS TRABECULAR STRUCTURE ON TRANSCRANIAL ULTRASOUND IMAGING IN THE PRESENCE OF ELASTIC WAVE MODE CONVERSION AT VARYING INCIDENCE ANGLE
EFFECT OF SKULL POROUS TRABECULAR STRUCTURE ON TRANSCRANIAL ULTRASOUND IMAGING IN THE PRESENCE OF ELASTIC WAVE MODE CONVERSION AT VARYING INCIDENCE ANGLE
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DOI：
10.1016/j.ultrasmedbio.2021.05.010
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发表时间：
2021-08-06
影响因子：
2.9
通讯作者：
Lindsey, Brooks D.
中科院分区：
文献类型：
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作者：
Jing, Bowen;Lindsey, Brooks D.
随着像差校正技术的进步，经颅超声成像在神经功能成像、引导治疗超声等方面显示出巨大的应用潜力。然而，由于颅骨声学特性的差异，经颅成像的可行性因人而异。为了更好地了解成像性能变化的基本机制，我们首次通过弹性波模拟和实验研究了多孔小梁骨结构对经颅成像性能（即目标定位误差和分辨率）的影响。利用离体颅骨样本的高分辨率计算机断层扫描数据进行的模拟研究表明，大入射角成像可以减少低孔隙率颅骨的目标定位误差；然而，随着颅骨孔隙度的增加，大入射角导致分辨率下降和目标定位误差增加。实验结果表明，正常入射角成像的定位误差为1.85 +/- 0.10 mm，大入射角（40）成像的定位误差增加了6.54 +/- 1.33 mm，导致单点目标在图像中不再是单一的相干目标，这与仿真结果一致。颅微结构对经颅超声成像影响的首次研究表明，成像性能高度依赖于颅骨的孔隙度，特别是在非正常入射角时。(电子邮件:布鲁克斯。(C) 2021年世界超声医学与生物学联合会。版权所有。
With the advancement of aberration correction techniques, transcranial ultrasound imaging has exhibited great potential in applications such as imaging neurological function and guiding therapeutic ultrasound. However, the feasibility of transcranial imaging varies among individuals because of the differences in skull acoustic properties. To better understand the fundamental mechanisms underlying the variation in imaging performance, the effect of the structure of the porous trabecular bone on transcranial imaging performance (i.e., target localization errors and resolution) was investigated for the first time through the use of elastic wave simulations and experiments. Simulation studies using high-resolution computed tomography data from ex vivo skull samples revealed that imaging at large incidence angles reduced the target localization error for skulls having low porosity; however, as skull porosity increased, large angles of incidence resulted in degradation of resolution and increased target localization errors. Experimental results indicate that imaging at normal incidence introduced a localization error of 1.85 +/- 0.10 mm, while imaging at a large incidence angle (40) resulted in an increased localization error of 6.54 +/- 1.33 mm and caused a single point target to no longer appear as a single, coherent target in the resulting image, which is consistent with simulation results. This first investigation of the effects of skull microstructure on transcranial ultrasound imaging indicates that imaging performance is highly dependent on the porosity of the skull, particularly at non-normal angles of incidence. (E-mail: brooks. lindsey@bme.gatech.edu) (C) 2021 World Federation for Ultrasound in Medicine & Biology. All rights reserved.