National survey of primary amenorrhea and relevant conditions in Japan
National survey of primary amenorrhea and relevant conditions in Japan
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日本全国原发性闭经及相关情况调查
DOI：
10.1111/jog.14606
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Kugu K.
中科院分区：
文献类型：
--
作者：
Haraguchi H;Harada M;Kashimada K;Horikawa R;Sakakibara H;Shozu M;Fujii T;Osuga Y;Kugu K.
在日本，大多数原发性闭经或相关疾病（如月经初潮延迟）的患者都是由儿科医生或妇科医生诊断的，因此，患者的数量和病因的比例尚不清楚。方法对2015年1月至2017年12月首次就诊的以月经初潮为主诉的患者进行问卷调查，向日本妇产科学会的596个专科医师培训机构和日本儿科学会理事会的152个设施提供了培训，结果我们收到了283（37.8%）机构的答复。3年内，1043例患者因未出现月经初潮而首次就诊于儿科或妇科。在303例首次访视时16岁以下的患者中，177例（58.4%）患者在16岁时月经初潮。其中41例（13.5%）月经初潮为自发性。在308名首次就诊时年龄在16至17岁的患者中，216名患者在调查时年龄在18岁或以上。其中124例（57.4%）患者在18岁时初潮，其中21例（9.7%）患者自发初潮。对462例闭经患者进行病因分析。包括特纳综合征的异常核型是最常见的122（26.4%），其次是苗勒管发育不全73（15.8%）。本报告将为临床医生提供更好的信息。
AimIn Japan, most of the patients with primary amenorrhea or related conditions, such as delayed menarche, are diagnosed by pediatricians or gynecologists; accordingly, the number of the patients and the ratio of the causes were unclear. To clarify them, we conducted a nationwide survey in both the departments for the first time.MethodsWe sent a questionnaire about the patients with chief complaint of no menarche whose first visit was from January 2015 to December 2017, to 596 training institutions for specialist physicians of the Japan Society of Obstetrics and Gynecology and 152 facilities to which councilors of the Japanese Society for Pediatric Endocrinology belong.ResultsWe received replies from 283 (37.8%) institutions. During the 3 years, 1043 patients first visited pediatrics or gynecology for no menarche. In 303 patients under 16 years old at the first visit, 177 (58.4%) patients had menarche by the age of 16. Of them, 41 (13.5%) patients had menarche spontaneously. Among 308 patients aged 16 to 17 at the first visit, 216 patients were 18 years or older at the survey. Of them, 124 (57.4%) patients had menarche by the age of 18, and 21 (9.7%) of them had menarche spontaneously. The causes of amenorrhea were detected in 462 patients. Abnormal karyotype including Turner syndrome was the most common at 122 (26.4%), followed by Mullerian agenesis at 73 (15.8%).ConclusionsThe first national survey revealed the number and causes of primary amenorrhea and related conditions. This report will provide better information for clinicians.
性发育迟缓：对 252 名患者的研究
影响因子：
9.8
作者：
R. Reindollar;J. Byrd;P. McDonough
通讯作者：
P. McDonough