The caudal periaqueductal gray participates in the activation of brown adipose tissue in rats
The caudal periaqueductal gray participates in the activation of brown adipose tissue in rats
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DOI：
10.1016/s0304-3940(02)00757-7
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发表时间：
2002-10-04
影响因子：
2.5
通讯作者：
Kanosue, K
中科院分区：
文献类型：
--
作者：
Chen, XM;Nishi, M;Kanosue, K
为探讨中脑导水管周围灰质（PAG）在非颤抖性产热中的作用，我们在乌拉坦麻醉的大鼠中检测了电刺激或化学刺激PAG对棕色脂肪组织（BAT）产热的影响。电刺激（0.1 mA，33 Hz，0.5 ms）或将D，L-同型半胱氨酸（0.5 mM，0.3穆尔）应用于尾侧PAG（cPAG）的外侧区域引起BAT产热，测量为肩胛间BAT的局部温度升高。这些结果表明，在cPAG神经元发出兴奋性传出信号BAT产热。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
To investigate the involvement of the periaqueductal gray (PAG) in the control of non-shivering thermogenesis, we tested the effects of electrical or chemical stimulation of the PAG on thermogenesis of brown adipose tissue (BAT) in urethane anesthetized rats. Electrical stimulation (0.1 mA, 33 Hz, 0.5 ms) or application of D,L-homocysteic acid (0.5 mM, 0.3 mul) into the lateral region of the caudal PAG (cPAG) elicited BAT thermogenesis, measured as a rise in the local temperature of interscapular BAT. These results suggest that neurons in the cPAG send excitatory efferent signals for BAT thermogenesis. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.