Is CD147 a New Biomarker Reflecting Histological Malignancy of Gliomas?
Is CD147 a New Biomarker Reflecting Histological Malignancy of Gliomas?
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DOI：
10.1007/s12035-016-9894-2
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发表时间：
2017-03-01
影响因子：
5.1
通讯作者：
Wang, Renzhi
中科院分区：
文献类型：
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作者：
Kong, Xiangyi;Wang, Yu;Wang, Renzhi
CD 147属于免疫球蛋白超家族，可刺激周围成纤维细胞分泌基质金属蛋白酶（MMPs）。研究表明，与正常组织相比，肺癌组织、乳腺癌组织和膀胱癌组织中的CD 47表达水平升高。它们随着肿瘤的恶性进展、侵袭性和转移而增加。然而，CD 147在WHO胶质瘤分级系统中的存在的确切意义和效用很少被报道;此外，关于CD 147的信号转导途径仍然不清楚和有争议。因此，在进行荟萃分析时，必须得出可靠的结论。将相关文献纳入本次Meta分析，并计算比值比（OR）及其95%可信区间（95%CI）。估计了杂合性评价。10项研究涉及615例患者，其中9项在中国进行，其余1项在日本进行。对涉及二分数据的八项研究的分析显示，胶质瘤组织中CD 147过表达与较高的WHO分级相关（III + IV; OR，9.900; 95%CI，5.943，16.491; P = 0.000），而对三项连续数据类型研究的分析表明，（标准平均差，-1.894; 95%CI，-4.081，0.293; P = 0.090）。漏斗图、Egger检验、Begg检验均无发表偏倚。考虑到连续数据仅占总体分析的一小部分，我们认为我们的研究表明CD 147过表达可能与较高的WHO分级相关。当然，需要更多基于循证医学的数据来进一步支持这一结论。
CD147 belongs to immunoglobulin superfamily and can stimulate the surrounding fibroblasts to secret matrix metalloproteinases (MMPs). Studies showed that when compared with their normal counterparts, CD47 expression level increased in lung carcinoma tissue, breast cancer tissue, and bladder cancer tissue. They increase in line with a tumor's malignant progression, invasiveness, and metastasis. However, the precise implications and utility of the presence of CD147 in the WHO grading system for gliomas have rarely been reported; in addition, the signal transduction pathways regarding CD147 remain unclear and controversial. Thus, in performing a meta-analysis, it is essential to reach a reliable conclusion. The related literatures were incorporated into the present meta-analysis after careful assessment, and odds ratios (ORs) with 95 % confidence intervals (95 % CIs) were calculated. Heterogeneity evaluation was estimated. Ten studies involving 615 patients were found to be eligible, nine of which were conducted in China and the remaining one in Japan. Analysis of eight studies involving dichotomous data revealed that CD147 overexpression in glioma tissue was related to higher WHO grading (III + IV; OR, 9.900; 95 % CI, 5.943, 16.491; P = 0.000) closely, whereas analysis of three studies of continuous data type indicated that there were no statistical associations (standard mean difference, -1.894; 95 % CI, -4.081, 0.293; P = 0.090). In accordance with funnel plot, Egger test, and Begg test, there was no publication bias. Considering that the continuous data make up only a small proportion of the overall analysis, we believe that our study indicates that CD147 overexpression is potentially related to higher WHO grade. Certainly, more data compiled based on evidence-based medicine are required to further support this conclusion.