Enzymes in Synthetic Organic Chemistry
Enzymes in Synthetic Organic Chemistry
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DOI：
10.1201/b11923-109
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发表时间：
1994-06
期刊：
影响因子：
--
通讯作者：
Chi‐Huey Wong;G. Whitesides
中科院分区：
文献类型：
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作者：
Chi‐Huey Wong;G. Whitesides
第1部分：酶催化反应的速率加速Michaelis-Menten动力学酶抑制特异性改善或改变酶特异性酶稳定和反应器配置辅助因子再生酶催化有机溶剂多酶系统和代谢工程的合理设计新的酶催化参考文献。第2部分水解酶的使用-酰胺酶、蛋白酶、酯酶、脂肪酶、腈酶、磷酸酶、环氧化物水解酶：酰胺酶、蛋白酶催化的肽合成酶，用作酯酶、乙酰胆碱酯酶、猪肝酯酶、磷脂酶、胆固醇酯酶、脂肪酶、腈水解酶、环氧化物水解酶、磷酸酶参考文献。第三部分氧化还原：烟酰胺辅助因子依赖的氧化还原脱氢酶，它利用酮酸作为底物，其他NAD(P)依赖的脱氢酶氧化还原酶是金属酶的参考。第四部分C-C键的形成：醛醇缩合酮醇和醛醇转移反应HCN加成到醛酰基丙酮缩合C-C键的形成反应涉及乙酰辅酶a异戊二烯和类固醇合成取代氯丙氨酸在维生素B催化下形成C-C键[0]文献。第5部分糖苷键的合成：糖基转移酶的背景Leloir途径底物特异性和糖基转移酶的合成应用非Leloir糖基转移酶糖苷酶转糖苷酶n-糖苷生物合成应用今后糖缀合物的合成机会参考。加成、消除和其他基团转移反应（磷酸基、甲基、硫基和氨基转移反应）：烯烃加水-富马酸酶-氨双键加成酶-氨解酶-转氨酶-氨基转移酶-三磷酸核苷羧基加成和消除需要酶法反应的ATP手性at -制备含-或-磷硫代酸的DNA和RNA DNA和RNA低聚物修饰或非天然碱基掺入DNA或RNA脱卤合成手性甲基s -腺苷蛋氨酸和转甲基化硫酸盐活化和转移反应。
Part 1 General aspects: rate acceleration in enzyme-catalyzed reactions Michaelis-Menten kinetics enzyme inhibition specificity improvement or alteration of enzyme specifity enzyme stabilization and reactor configuration cofactor regeneration enzyme catalysis in organic solvents multienzyme systems and metabolic engineering rational design of new enzymatic catalysts references. Part 2 Use of hydrolytic enzymes - amidases, proteases, esterases, lipases, nitrilases, phosphatases, epoxide hydrolases: amidases protease-catalyzed peptide synthesis proteases that act as esterases acetylcholine esterase pig liver esterase phospholipases cholesterol esterase lipases nitrile hydrolysis enzymes epoxide hydrolase phosphatase references. Part 3 Oxidoreductions: nicotinamide cofactor dependent oxidoreductions dehydrogenases which utilize ketoacids as substrates other NAD(P)-dependent dehydrogenases oxidoreductases that are metalloenzymes references. Part 4 C-C bond formation: aldol condensation ketol and aldol transfer reaction addition of HCN to aldehydes acyloin condensation C-C bond forming reactions involving acetyl coA isoprenoid and steroid synthesis replacement of chloroalanine C-C bond formation catalyzed by vitamin B[12] references. Part 5 Synthesis of glycoside bonds: background glycosyltransferases of the Leloir pathway substrate specificity and synthetic applications of glycosyltransferases non-leloir glycosyltransferases glycosidases transglycosidases synthesis of N-glycosides biological applications of synthetic glycoconjugates future opportunities references. Part 6 Addition, elimination and other group transfer reactions (phosphoryl-, methyl-,sulpho-and amino-transfer reactions): addition of water to alkenes - fumarase addition of ammonia to double bonds - ammonia lyases transamination - aminotransferases addition and elimination of carboxyl group nucleoside triphosphate requiring enzymatic reactions preparation of ATP chiral at -, - or - phosphorous phosphorothioate-containing DNA and RNA DNA and RNA oligomers incorporation of modified or unnatural bases into DNA or RNA dehalogenation synthesis of chiral methyl groups S-adenosylmethionine and transmethylation sulfate activation and transfer reactions.