AUTORADIOGRAPHIC LOCALIZATION OF OPIATE RECEPTORS IN RAT-BRAIN .3. TELENCEPHALON
AUTORADIOGRAPHIC LOCALIZATION OF OPIATE RECEPTORS IN RAT-BRAIN .3. TELENCEPHALON
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DOI：
10.1016/0006-8993(77)90817-4
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发表时间：
1977-01-01
期刊：
影响因子：
2.9
通讯作者：
KUHAR, MJ
中科院分区：
文献类型：
--
作者：
ATWEH, SF;KUHAR, MJ
阿片受体的分布，确定立体特异性[3H]二丙诺啡结合位点的放射自显影定位，检查端脑。区域显示非常密集或密集的本地化的受体包括部分前下托和杏仁核，斑片状区域的尾壳核和延髓，穹窿下器，终纹的纹状体间核和前嗅核，pars externa。海马结构其他部位、大脑皮质深部、脚内核、苍白球、三角隔核和带旁核密度较低。这些研究结果的意义进行了讨论的阿片类药物的生化和生理作用。
Opiate receptor distribution, determined by the autoradiographic localization of stereospecific [3H]diprenorphine binding sites, was examined in the telencephalon. Areas showing very dense or dense localization of receptors included parts of the presubiculum and amygdala, patchy areas in the caudate-putamen and accumbens, the subfornical organ, the interstriatal nucleus of the striae terminalis and the anterior olfactory nucleus, pars externa. Lower densities were found in other parts of the hippocampal formation, the deeper part of the cerebral cortex, the entopeduncular nucleus, globus pallidus, nucleus triangularis septi and nucleus paratenialis. The significance of these findings was discussed in terms of the biochemical and physiological actions of opiates.