Palladium-Catalyzed Tandem Reaction of Alkyne-Based Aryl Iodides and Salicyl N-Tosylhydrazones to Construct the Spiro[benzofuran-3,2 '-chromene] Skeleton
Palladium-Catalyzed Tandem Reaction of Alkyne-Based Aryl Iodides and Salicyl N-Tosylhydrazones to Construct the Spiro[benzofuran-3,2 '-chromene] Skeleton
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DOI：
10.1002/adsc.201501150
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发表时间：
2016
影响因子：
5.4
通讯作者：
Liu Pei Nian
中科院分区：
文献类型：
--
作者：
Shang Xue Song;Li Nian Tai;Li Deng Yuan;Liu Pei Nian
在钯的催化下，芳基碘化物和水杨基N-对甲苯磺酰肼进行了方便的串联反应，合成了一系列含有新型螺环[苯并呋喃-3，2‘-色烯]支架的化合物，产率中等到很高。这种高效的催化反应，可以容忍不同的官能团，结合了基于炔基的5-外二环化、钯(II)卡宾迁移插入和分子内环化，在一个反应中产生了三个新的键。
A convenient palladium‐catalyzed tandem reaction of aryl iodides and salicylN‐tosylhydrazones has been achieved to afford a series of compounds containing the novel spiro[benzofuran‐3,2′‐chromene] scaffold in moderate to good yields. This efficient catalytic reaction, which tolerates various functional groups, combines alkyne‐based 5‐exo‐digcyclization, palladium(II) carbene migratory insertion and intramolecular cyclization, generating three new bonds in one reaction.