Untangling tau imaging.
Untangling tau imaging.
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DOI：
10.1016/j.dadm.2016.05.001
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Rowe CC
中科院分区：
文献类型：
--
作者：
Villemagne VL;Okamura N;Rowe CC
tau沉积物的体内成像提供了对大脑中时间和空间tau沉积的更好理解，允许更全面地了解tau蛋白病的原因、诊断和潜在治疗，例如阿尔茨海默病、进行性核上性麻痹、皮质基底综合征、慢性创伤性脑病和额颞叶变性的一些变体。随着时间的推移，对tau蛋白在大脑中沉积的评估将使人们更深入地了解tau蛋白与其他变量（如认知、基因型和神经退行性变）之间的关系，并评估tau蛋白在衰老中的作用。初步的人体研究表明，tau成像也可用作诊断、预后和治疗诊断生物标志物，以及用于靶向接合、患者招募和疾病特异性治疗试验的疗效监测的替代标志物。
In vivo imaging of tau deposits is providing a better understanding of the temporal and spatial tau deposition in the brain, allowing a more comprehensive insight into the causes, diagnoses, and potentially treatment of tauopathies such as Alzheimer's disease, progressive supranuclear palsy, corticobasal syndrome, chronic traumatic encephalopathy, and some variants of frontotemporal lobar degeneration. The assessment of tau deposition in the brain over time will allow a deeper understanding of the relationship between tau and other variables such as cognition, genotype, and neurodegeneration, as well as assessing the role tau plays in ageing. Preliminary human studies suggest that tau imaging could also be used as a diagnostic, prognostic, and theranostic biomarker, as well as a surrogate marker for target engagement, patient recruitment, and efficacy monitoring for disease-specific therapeutic trials.