Reanalysis of the refractory period in exertional asthma.
Reanalysis of the refractory period in exertional asthma.
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劳力性哮喘不应期的重新分析。
DOI：
10.1152/jappl.1981.50.3.503
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
IngramJr,RH
中科院分区：
文献类型：
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作者：
Stearns,DR;McFaddenJr,ER;Breslin,FJ;IngramJr,RH
为了确定运动性哮喘的不应期是否来自介质的消耗，我们让7名哮喘受试者在精确控制的吸气空气条件下，在匹配的分钟通气条件下反复进行运动和呼吸过度通气。我们推断，如果气道冷却导致一种药剂释放，其耗竭导致反应性降低，我们应该能够观察到这种现象，而不管冷却是如何产生的。在短时间间隔的重复运动中，阻塞性反应减少，当挑战之间的间隔延长到2小时时，阻塞性反应消失。然而，无论何时进行挑衅，自愿过度通气后发生的阻塞程度保持不变，与第一次和最后一次运动挑战时的情况相同。由于每次挑战和所有时间段的热负荷都是相同的，因此这些结果与介质耗竭不相容，并表明可能是重复运动的继发性交感肾上腺后果导致气道暂时失去反应性。
In an effort to determine whether the refractory period in exercise-induced asthma derived from mediator consumption we had seven asthmatic subjects repeatedly perform both exercise and eucapnic hyperventilation at matched minute ventilations under precisely controlled inspired air conditions. We reasoned that, if airway cooling were causing an agent to be released whose depletion resulted in less responsiveness, we should be able to observe this phenomenon irrespective of how cooling was produced. Repetitive exercise at short intervals produced a diminution in the obstructive response that disappeared when the interval between challenges was extended to 2 h. However, the degree of obstruction that occurred after voluntary hyperventilation remained constant irrespective of when the provocations were performed and equaled that seen with the first and last exercise challenge. Because the thermal burdens were identical for each challenge and all time periods, these results are incompatible with mediator depletion and suggest that it may be the secondary sympathoadrenal consequences of repeated exercise that cause the airways to temporarily lose their responsivity.