Cerebellar Contribution to Preparatory Activity in Motor Neocortex
Cerebellar Contribution to Preparatory Activity in Motor Neocortex
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DOI：
10.1016/j.neuron.2019.05.022
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发表时间：
2019-08-07
期刊：
影响因子：
16.2
通讯作者：
Mrsic-Flogel, Thomas D.
中科院分区：
文献类型：
--
作者：
Chabrol, Francois P.;Blot, Antonin;Mrsic-Flogel, Thomas D.
在运动新皮层，预测特定运动的准备活动由丘脑的正反馈回路维持。运动丘脑接收来自小脑的兴奋性输入，小脑学习产生运动控制的预测信号。这条通路对新皮层预备信号的贡献仍然知之甚少。在这里，我们表明，在一个虚拟现实条件反射任务，小脑输出神经元在齿状核表现出类似的前外侧运动皮层奖励收购前的准备活动。通过光激活小脑皮层中的抑制性浦肯野细胞来沉默齿状核中的活动，导致前外侧运动皮层中的准备活动受到强有力的短潜伏期抑制。我们的研究结果表明，准备活动控制的学习减少浦肯野细胞发射提前奖励的监督下攀登纤维输入信号奖励交付。因此，小脑计算对运动新皮层的准备活动产生了强大的影响。
In motor neocortex, preparatory activity predictive of specific movements is maintained by a positive feedback loop with the thalamus. Motor thalamus receives excitatory input from the cerebellum, which learns to generate predictive signals for motor control. The contribution of this pathway to neocortical preparatory signals remains poorly understood. Here, we show that, in a virtual reality conditioning task, cerebellar output neurons in the dentate nucleus exhibit preparatory activity similar to that in anterolateral motor cortex prior to reward acquisition. Silencing activity in dentate nucleus by photo-activating inhibitory Purkinje cells in the cerebellar cortex caused robust, short-latency suppression of preparatory activity in anterolateral motor cortex. Our results suggest that preparatory activity is controlled by a learned decrease of Purkinje cell firing in advance of reward under supervision of climbing fiber inputs signaling reward delivery. Thus, cerebellar computations exert a powerful influence on preparatory activity in motor neocortex.