Myeloperoxidase Levels and Mortality in Frail Community-Living Elderly Individuals
Myeloperoxidase Levels and Mortality in Frail Community-Living Elderly Individuals
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DOI：
10.1093/gerona/glp183
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发表时间：
2010-04-01
影响因子：
5.1
通讯作者：
Landi, Francesco
中科院分区：
文献类型：
--
作者：
Giovannini, Silvia;Onder, Graziano;Landi, Francesco
背景。髓过氧化物酶（MPO）的全身水平升高与不良的临床结果相关。在本研究中，我们评估了 MPO（一种促氧化酶，可催化脂质过氧化的启动并影响一氧化氮水平）对社区中大量体弱的八十多岁和九十多岁老年人全因死亡风险的影响。方法。我们分析了 Sirente 地理区域的老龄化和长寿研究（iISIRENTE 研究）的数据，这是一项前瞻性队列研究，收集了居住在一个山区社区的所有 80 岁及以上个体的数据（n = 363）。主要结果指标是 4 年随访后的死亡风险。根据 MPO 三分位数将参与者分为三组：下三分位数 = 140.7 mu g/L (n = 123)。结果。 4 年随访期间共有 150 人死亡。死亡者的平均 MPO 水平为 170.8 +/- 177.5 μg/L，而幸存者的平均 MPO 水平为 135.4 +/- 142.4 μg/L (p = .03)。与处于较低三分位数的个体 (26% [39/120]) 相比，处于最高 M PO 三分位数的个体具有更高的死亡风险 (40%[60/123])。在调整潜在的混杂因素后，与较低三分位数的参与者进行比较。处于较高三分位的患者的死亡率风险比为 1.97（95% 置信区间：1.02-3.80）。结论。我们从高龄和虚弱老年人的代表性样本中获得的结果扩展了人们对低 MPO 水平与更好生存相关的认识。
Background. Elevated systemic levels of myeloperoxidase (MPO) have been associated with unfavourable clinical outcomes. In the present study, we evaluate the impact of MPO, a pro-oxidant enzyme that catalyzes the initiation of lipid peroxidation and affects nitric oxide levels, on the risk of all-cause mortality in a large population of frail octogenarians and nonagenarians living in community.Methods. We analyzed data from the Aging and Longevity Study in the Sirente Geographic Area (iISIRENTE Study), a prospective cohort study that collected data on all individuals aged 80 years and older living in a inountain community (n = 363). The main outcome measure was the risk of death after 4 years of follow-up. Participants were divided into three groups based on MPO tertiles: lower tertile = 140.7 mu g/L (n = 123).Results. A total of 150 deaths occurred during 4-years follow-up. The mean MPO level was 170.8 +/- 177.5 mu g/L among those who died compared with 135.4 +/- 142.4 mu g/L, among survivors (p = .03). Individuals in the highest M PO tertile had higher risk of mortality (40%[60/123]) compared with those in the lower tertile (26% [39/120]). After adjusting for potential confounders, compared with participants in the lower tertile. those in the higher tertile had a hazard ratio for mortality of 1.97 (95% confidence interval: 1.02-3.80).Conclusion. Our results obtained from a representative sample of very old and frail elderly individuals expand the knowledge that low levels of MPO are associated with better survival.