Marked therapeutic effect of dimyristoylphosphatidylcholine liposomes on carcinoma mice model in vivo.
Marked therapeutic effect of dimyristoylphosphatidylcholine liposomes on carcinoma mice model in vivo.
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二肉豆蔻酰磷脂酰胆碱脂质体对体内癌症小鼠模型有显着的治疗作用。
DOI：
10.1248/bpb.23.1262
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发表时间：
2000
影响因子：
2
通讯作者：
H. Ichihara
中科院分区：
文献类型：
--
作者：
R. Ueoka;Y. Matsumoto;A. Kanno;K. Tsuzaki;H. Ichihara
首次在不给药的情况下给药二myristoylphosphatidylcholine （DMPC）单组分脂质体后，肿瘤小鼠模型的存活率明显延长。光学显微镜下观察到淋巴细胞增加，但中性粒细胞计数未见增加，提示DMPC脂质体可能抑制肿瘤生长，抑制体内淋巴细胞增加。
Significantly prolonged survival rate was obtained for the first time using carcinoma mice models after the administration of single-component liposomes of dimyristoylphosphatidylcholine (DMPC) without any drug. An increase in lymphocytes under optical microscope was observed without any increase in the neutrophils count, suggesting that the DMPC liposomes might inhibit the tumor growth as well as increase in lymphocytes in vivo.