'Reducing Delays In Vaccination' (REDIVAC) trial: a protocol for a randomised controlled trial of a web-based, individually tailored, educational intervention to improve timeliness of infant vaccination
'Reducing Delays In Vaccination' (REDIVAC) trial: a protocol for a randomised controlled trial of a web-based, individually tailored, educational intervention to improve timeliness of infant vaccination
复制标题
DOI：
10.1136/bmjopen-2018-027968
复制
发表时间：
2019-05-01
期刊：
影响因子：
2.9
通讯作者：
Glanz, Jason M.
中科院分区：
文献类型：
--
作者：
Dempsey, Amanda F.;Wagner, Nicole;Glanz, Jason M.
简介越来越多的儿童没有接种许多推荐的疫苗，这导致了美国和世界各地疫苗可预防疾病的重大爆发。疫苗接种不足的一个主要驱动因素是父母对疫苗的犹豫不决。先前的研究表明，母亲是婴儿接种疫苗的主要决策者，她们的接种态度主要是在怀孕期间和婴儿生命早期形成的。方法和分析这篇手稿描述了在科罗拉多州凯撒永久医院(Kaiser Permanente Colorado)正在进行的三臂随机对照试验的方案。这项试验的目的是测试通过互联网向孕妇和新妈妈提供定制的、个性化的信息与非定制的信息与常规护理相比在婴儿接种疫苗的及时性方面的有效性。要评估的主要结果是疫苗接种状况，这是在出生200天时评估的两种结果(最新和没有)，反映了婴儿应该完成第一套疫苗接种的时间(在2、4和6个月时)。延迟至少30天接种一种或多种适龄推荐疫苗的婴儿被归类为不是最新的，而所有其他婴儿被认为是最新的。次要结果包括出生489天时的疫苗接种状况，反映了12-15个月龄时接受推荐疫苗的情况，以及接种态度、犹豫不决和意图。疫苗接种数据将来自电子病历和州免疫登记。其他次要结果将通过在线调查进行评估。道德和传播研究活动得到了科罗拉多大学、科罗拉多大学、科罗拉多大学和密歇根大学机构审查委员会的批准。结果将通过同行评议的手稿和会议演示文稿传播。
Introduction Increasing numbers of children are failing to receive many recommended vaccines, which has led to significant outbreaks of vaccine-preventable diseases in the USA and worldwide. A major driver of undervaccination is parental vaccine hesitance. Prior research demonstrates that mothers are the primary decision maker for infant vaccination, and that their vaccination attitudes form primarily during pregnancy and early in their infant's life.Methods and analysis This manuscript describes the protocol for an ongoing three-armed randomised controlled trial done at Kaiser Permanente Colorado (KPCO). The trial aims to test the efficacy of provided tailored, individualised information via the Internet to pregnant and new mothers versus untailored information versus usual care on the timeliness of infant vaccination. The primary outcome to be assessed is vaccination status, which is a dichotomous outcome (up to date vs not) assessed at age 200 days, reflecting the time when infants should have completed the first set of vaccine provided (at age 2, 4 and 6 months). Infants with one or more age-appropriate recommended vaccines at least 30 days delayed are categorised as not up to date whereas all other infants are considered up to date. Secondary outcomes include vaccination status at age 489 days, reflecting receipt of recommended vaccines at age 12-15 months, as well as vaccination attitudes, hesitancy and intention. Vaccination data will be derived from the electronic medical record and the state immunisation registry. Other secondary outcomes will be assessed by online surveys.Ethics and dissemination The study activities were approved by the Institutional Review Boards of the University of Colorado, KPCO and the University of Michigan. Results will be disseminated through peer-reviewed manuscripts and conference presentations.