LIMITATION OF FECAL AND PHARYNGEAL POLIOVIRUS EXCRETION IN SALK-VACCINATED CHILDREN - A FAMILY STUDY DURING A TYPE 1 POLIOMYELITIS EPIDEMIC
LIMITATION OF FECAL AND PHARYNGEAL POLIOVIRUS EXCRETION IN SALK-VACCINATED CHILDREN - A FAMILY STUDY DURING A TYPE 1 POLIOMYELITIS EPIDEMIC
复制标题
DOI：
10.1093/oxfordjournals.aje.a120272
复制
发表时间：
1962-01-01
影响因子：
--
通讯作者：
CHIN, TDY
中科院分区：
文献类型：
--
作者：
MARINE, WM;GRAVELLE, CR;CHIN, TDY
在1960年罗德岛脊髓灰质炎流行期间，对55个家庭进行了Salk疫苗接种和中和抗体水平对脊髓灰质炎病毒家庭传播的影响的研究。所有15个指标家系、29个接触者家庭中的18个和11个非接触者家庭中的5个均发现有脊髓灰质炎病毒1型感染。在没有检测到抗体的受感染儿童中，60%出现了轻微疾病，但滴度为128+的儿童中只有24%出现了轻微疾病。从75%的未检出抗体的感染儿童中分离到咽病毒，从滴度8到的38%和滴度128+的25%中分离到咽病毒。尽管无论抗体效价或既往免疫史，感染家庭的成员都有足够的家庭内传播，但家庭外传播仅限于接种疫苗较少的接触者家庭。
The effect of Salk vaccination and neutralizing antibody level on family spread of poliovirus was studied in 55 families during the 1960 Rhode Island poliomyelitis epidemic. All 15 index families, 18 of 29 contact families and 5 of 11 noncontact families were found to have poliovirus type 1 infection. Minor illnesses occurred in 60% of the infected children having no detectable antibodies, but in only 24% with titers of 128+. Pharyngeal virus was isolated from 75% of infected children having no detectable antibodies, from 38% with titers 8 to 64 and from 25% with titers 128+. Although intra-familial spread occurred enough members of infected families irrespective of antibody titer or past immunization, extrafamilial spread was restricted to the poorly vaccinated contact families.