HIV-1 dynamics in vivo: Virion clearance rate, infected cell life-span, and viral generation time
HIV-1 dynamics in vivo: Virion clearance rate, infected cell life-span, and viral generation time
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DOI：
10.1126/science.271.5255.1582
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发表时间：
1996-03-15
期刊：
影响因子：
56.9
通讯作者：
Ho, DD
中科院分区：
文献类型：
--
作者：
Perelson, AS;Neumann, AU;Ho, DD
一种新的数学模型被用来分析一组详细的人类免疫缺陷病毒1型（HIV-1）病毒载量数据收集从5个感染的个人后，管理的一个有效的抑制剂HIV-1蛋白酶。据估计，生产性感染细胞的平均寿命为2.2天（半衰期t（1/2）= 1.6天），血浆病毒体的平均寿命为0.3天（t（1/2）= 0.24天）。估计HIV-1病毒粒子的平均总产量为每天10.3x10（9）个，大大高于以前的最低估计数。结果还表明，HIV-1在体内的生命周期的最短持续时间平均为1.2天，而HIV-1的平均生成时间-定义为从病毒体释放到感染另一个细胞并导致新一代病毒颗粒释放的时间-为2.6天。这些关于病毒动力学的发现不仅提供了HIV-1发病机制的动力学图片，同时也是指导治疗策略制定的理论原则。
A new mathematical model was used to analyze a detailed set of human immunodeficiency virus-type 1 (HIV-1) viral load data collected from five infected individuals after the administration of a potent inhibitor of HIV-1 protease. Productively infected cells were estimated to have, on average, a life-span of 2.2 days (half-life t(1/2) = 1.6 days), and plasma virions were estimated to have a mean life-span of 0.3 days (t(1/2) = 0.24 days). The estimated average total HIV-1 production was 10.3 x 10(9) virions per day, which is substantially greater than previous minimum estimates. The results also suggest that the minimum duration of the HIV-1 life cycle in vivo is 1.2 days on average, and that the average HIV-1 generation time-defined as the time from release of a virion until it infects another cell and causes the release of a new generation of viral particles-is 2.6 days, These findings on viral dynamics provide not only a kinetic picture of HIV-1 pathogenesis, but also theoretical principles to guide the development of treatment strategies.