The Promises and Challenges of Stem Cells Use for Orthopedic Applications: A New and Exciting Era in Biological Treatments.
The Promises and Challenges of Stem Cells Use for Orthopedic Applications: A New and Exciting Era in Biological Treatments.
复制标题
干细胞用于骨科应用的前景和挑战：生物治疗的一个令人兴奋的新时代。
DOI：
10.1097/bto.0000000000000417
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Drissi,Hicham
中科院分区：
文献类型：
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作者：
Drissi,Hicham
干细胞在骨科实践中的使用呈指数级增长。因此，干细胞已被确定具有广泛的功能。有些人认为它们是免疫调节剂的天然来源，而另一些人则将它们用于再生医学目的。一些研究小组正在评估干细胞转化为临床实践的潜力，而医生们一直在实践中使用经过最低限度操作的自体干细胞来治疗患者。在本期中，我们想讨论干细胞生物学、功能和治疗潜力的一些关键方面，特别关注骨科。通过比较自体和同种异体间充质干细胞注射到膝关节及其减缓骨关节炎疾病进展的潜在益处，我们承认干细胞治疗膝骨关节炎的进展。与这个有趣的主题相关，并解决围绕干细胞治疗膝关节骨关节炎（特别是骨科）的一些有争议的问题，本次研讨会还深入了解了美国的卫生政策、监管和临床发展，以及与其他国家相比美国干细胞临床应用的市场准入。由于我们的领域涵盖所有年龄段，因此重点讨论了干细胞在儿科骨科应用中的应用 成骨不全、低磷酸酯酶症和骨再生。此外，还讨论了间充质干细胞替代品的使用。随着患有退行性椎间盘疾病和椎间盘源性背部和颈部疼痛的患者数量不断增加，脊柱领域的科学和临床界一直在积极关注以下方面的潜在益处：
The use of stem cells in orthopedic practice has been increasing exponentially. Thus, stem cells have been identified to have wide ranging functions. Where some have identified them as a natural source of immune modulators, others have utilized them for regenerative medicine purposes. Some investigative teams are working on evaluating the potential of stem cells for translation into clinical practice, while physicians have been using minimally manipulated autologous stem cells in their practice to treat their patients. In this issue, we wanted to discuss some critical aspects of stem cells biology, function and therapeutic potential, with a specific focus on orthopedics. We acknowledge the advancement of stem cell therapy for knee osteoarthritis with a comparison between autologous and allogeneic mesenchymal stem cell injections into the knee joint and their potential benefit to slow down osteoarthritis disease progression. Related to this interesting topic and to address some of the controversial issues around stem cell therapy for knee OA in particular and in orthopedics in general, this symposium also provides an insight into the health policy, regulatory, and clinical development, as well as market access of the clinical use of stem cells in the United States compared with other countries.As our field spans all ages, the use of stem cells for pediatric orthopedic applications is covered with an emphasis on osteogenesis imperfecta, hypophosphatasia, and bone regeneration. Moreover, the use of mesenchymal stem cells alternatives is also discussed. With the ever-increasing number of patients with degenerative disk disease and discogenic back and neck pain, the scientific and clinical community in the spine field has been actively focusing on the potential benefits on