High lymph node yield is related to microsatellite instability in colon cancer.
High lymph node yield is related to microsatellite instability in colon cancer.
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DOI：
10.1245/s10434-011-2091-7
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发表时间：
2012-04
影响因子：
3.7
通讯作者：
Meijer GA
中科院分区：
文献类型：
--
作者：
Belt EJ;te Velde EA;Krijgsman O;Brosens RP;Tijssen M;van Essen HF;Stockmann HB;Bril H;Carvalho B;Ylstra B;Bonjer HJ;Meijer GA
结肠癌切除标本的淋巴结（LN）产出率是衡量治疗质量的重要指标，尤其对早期患者具有治疗意义。然而，潜在的疾病机制，如微卫星不稳定性（MSI），也可能影响LN的产生，因为已知MSI肿瘤表现出更突出的淋巴细胞抗肿瘤反应。本研究的目的是探讨结肠癌中LN生成、MSI状态和复发率之间的关系。收集了332例II期和III期结肠癌患者的临床病理资料和肿瘤样本。分离DNA并进行pcr - MSI分析。当提取到10个或更多的LN时，LN收率被定义为“高”，当提取不到10个LN时，LN收率被定义为“低”。高LN含量的肿瘤与MSI表型显著相关（高LN含量：MSI肿瘤26.3% vs低LN含量：MSI肿瘤15.1%,P = 0.01），主要发生在III期疾病。与低淋巴结转移患者相比，高淋巴结转移患者的复发率较低。与MSS肿瘤患者相比，MSI肿瘤患者的复发率更低，主要发生在II期。在本研究中，高LN产率与MSI肿瘤相关，主要发生在III期患者。除了适当的手术和病理外，高LN产率可能是MSI肿瘤的生物学行为所致。
Lymph node (LN) yield in colon cancer resection specimens is an important indicator of treatment quality and has especially in early-stage patients therapeutic implications. However, underlying disease mechanisms, such as microsatellite instability (MSI), may also influence LN yield, as MSI tumors are known to exhibit more prominent lymphocytic antitumor reactions. The aim of the present study was to investigate the association of LN yield, MSI status, and recurrence rate in colon cancer. Clinicopathological data and tumor samples were collected from 332 stage II and III colon cancer patients. DNA was isolated and PCR-based MSI analysis performed. LN yield was defined as “high” when 10 or more LNs were retrieved and “low” in case of fewer than 10 LNs. Tumors with high LN yield were significantly associated with the MSI phenotype (high LN yield: 26.3% MSI tumors vs low LN yield: 15.1% MSI tumors; P = .01), mainly in stage III disease. Stage II patients with high LN yield had a lower recurrence rate compared with those with low LN yield. Patients with MSI tumors tended to develop fewer recurrences compared with those with MSS tumors, mainly in stage II disease. In the present study, high LN yield was associated with MSI tumors, mainly in stage III patients. Besides adequate surgery and pathology, high LN yield is possibly a feature caused by biologic behavior of MSI tumors.
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影响因子：
29.4
作者：
Boland CR;Goel A
通讯作者：
Goel A
影响因子：
9
作者：
Chen, Steven L.;Bilchik, Anton J.
通讯作者：
Bilchik, Anton J.
影响因子：
24.5
作者：
Jass, JR;Do, KA;Leggett, B
通讯作者：
Leggett, B
影响因子：
2.6
作者：
Cianchi, F;Palomba, A;Cortesini, C
通讯作者：
Cortesini, C
影响因子：
3.8
作者：
Moore, Jesse;Hyman, Neil;Littenberg, Benjamin
通讯作者：
Littenberg, Benjamin