Inhibition of mitochondrial carnitine palmitoyl transferase by 2-tetradecylglycidic acid (McN-3802) (preliminary communication).
Inhibition of mitochondrial carnitine palmitoyl transferase by 2-tetradecylglycidic acid (McN-3802) (preliminary communication).
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2-十四烷基缩水甘油酸 (McN-3802) 对线粒体肉毒碱棕榈酰转移酶的抑制（初步通讯）。
DOI：
10.1016/0024-3205(80)90156-3
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发表时间：
1980
期刊：
影响因子：
6.1
通讯作者：
M. T. Ryzlak
中科院分区：
文献类型：
--
作者：
G. Tutwiler;M. T. Ryzlak
据报道，口服降糖药2-十四烷基缩水甘油酸（McN-3802）可抑制离体大鼠肝细胞和肌肉制剂中长链脂肪酸的氧化，但不抑制短链脂肪酸的氧化，可抑制大鼠肝线粒体对棕榈酰CoA和棕榈酸的氧化。药物本身是一种脂肪酸类似物，不会被线粒体氧化。有证据表明，2-十四烷基缩水甘油酸（或其辅酶A酯）通过不可逆地抑制线粒体肉毒碱棕榈酰转移酶来抑制脂肪酸氧化。该药物不抑制线粒体棕榈酰辅酶A合成酶。
The oral hypoglycemic agent, 2-tetradecylglycidic acid (McN-3802), which has been reported to inhibit the oxidation of long chain but not short chain fatty acids in isolated rat hepatocytes and muscle preparations, inhibited the oxidation of palmitoyl CoA and palmitic acid by rat liver mitochondria. The drug itself, which is a fatty acid analog, was not oxidized by mitochondria. Evidence is presented that 2-tetradecylglycidic acid (or its coenzyme A ester) inhibits fatty acid oxidation by irreversibly inhibiting mitochondrial carnitine palmitoyltransferase. The drug did not inhibit mitochondrial palmitoyl-CoA synthetase.