COMPARISON OF THE IMMUNE-RESPONSE TO EPSTEIN-BARR-VIRUS AND CYTOMEGALOVIRUS IN SERA AND SYNOVIAL-FLUIDS OF PATIENTS WITH RHEUMATOID-ARTHRITIS
COMPARISON OF THE IMMUNE-RESPONSE TO EPSTEIN-BARR-VIRUS AND CYTOMEGALOVIRUS IN SERA AND SYNOVIAL-FLUIDS OF PATIENTS WITH RHEUMATOID-ARTHRITIS
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DOI：
10.1136/ard.46.11.837
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发表时间：
1987-11-01
影响因子：
27.4
通讯作者：
LAPLACA, M
中科院分区：
文献类型：
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作者：
MUSIANI, M;ZERBINI, M;LAPLACA, M
在类风湿性关节炎（RA）患者的血清和匹配的滑液中测定了对两种疱疹病毒的免疫反应，并与健康对照人群进行了比较。在RA患者中，eb病毒（EBV）诱导抗原的抗体水平升高与巨细胞病毒（CMV）诱导抗原的抗体模式相似，这表明RA患者中存在一种可以重新激活潜伏病毒感染的病理状态。在滑液中观察到的针对EBV和CMV的抗体反应排除了针对EBV和CMV抗原的特异性抗体的局部产生。
The immune response against two herpesviruses has been determined in sera and matched synovial fluids of patients with rheumatoid arthritis (RA) and compared with that of a healthy control population. The increased level of antibody to Epstein-Barr virus (EBV) induced antigens in patients with RA resembles the antibody pattern observed against cytomegalovirus (CMV) induced antigens, which suggests the presence of a pathological condition in patients with RA that can reactivate latent viral infections. The antibody response against EBV and CMV observed in synovial fluids excludes the local production of specific antibodies against EBV and CMV antigens.