Pathology of aging B6;129 mice
Pathology of aging B6;129 mice
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DOI：
10.1080/019262301753385988
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发表时间：
2001-11-01
影响因子：
1.5
通讯作者：
Ward, JM
中科院分区：
文献类型：
--
作者：
Haines, DC;Chattopadhyay, S;Ward, JM
将50只雄性和49只雌性B6;129小鼠（野生型，+/+）饲养至2岁，以研究其年龄相关病理学。到104-105周，14/50（28%）的雄性和30/49（61%）的雌性仍然存活。最常见的发病或死亡原因是淋巴瘤。在21/50（42%）只雄性和33/49（67%）只雌性中观察到淋巴瘤，最常见部位为肠系膜淋巴结、肠道相关淋巴组织（派尔集合淋巴结）和脾脏。淋巴瘤最常出现在肠系膜淋巴结。免疫组化显示CD 45 R表达以及许多CD 3+细胞浸润。IgH基因重排被发现在典型的肠系膜淋巴结淋巴瘤表明B细胞起源。它们与人类富含T细胞的B细胞淋巴瘤相似。其他肿瘤包括肝细胞腺瘤或癌（男性12%，女性10%）、肺泡II型细胞腺瘤或癌（男性32%，女性20%）、甲状腺滤泡性腺瘤或癌（男性2%，女性8%）、卵巢肿瘤（17%）和子宫内膜肿瘤（6%）。非肿瘤性病变包括淀粉样物质在鼻中隔（男女各100%），中耳炎（男性84%，女性79%），附睾上皮细胞核肥大（88%），黑变病（各种组织，包括脑、甲状旁腺和脾的高发生率），膜增生性肾小球肾炎（男性52%，女性71%），玻璃样变性伴多个组织中的细胞外晶体（呼吸道、胆囊、胃）、胰岛细胞增生（男45%，女29%）和食管扩张（男10%，女6%）。B6; 129小鼠是一种具有与其他小鼠品系相似的衰老病变但具有特征性常见淋巴瘤的小鼠。
Fifty male and 49 female B6;129 mice (wild-type, +/+) were maintained until 2 years of age to study their age-related pathology. By 104-105 weeks, 14/50 (28%) of the males and 30/49 (61%) of the females were still alive. The most common contributing cause of morbidity or mortality was lymphoma. Lymphoma was observed in 21/50 (42%) of the males and 33/49 (67%) of the females with the most common sites being mesenteric lymph nodes, gut associated lymphoid tissue (Peyer's patches), and spleen. The lymphoma most often appeared to arise in the mesenteric node. Immunohistochemistry revealed CD45R expression as well as infiltration by many CD3+ cells. IgH gene rearrangements were found in typical mesenteric node lymphomas indicating B-cell origin. They bore similarities to the human T-cell rich, B-cell lymphomas. Other tumors included hepatocellular adenoma or carcinoma (male 12%, females 10%), lung alveolar Type II cell adenoma or carcinoma (male 32%, female 20%), thyroid follicular adenoma or carcinoma (male 2%, female 8%), ovarian tumors (17%), and endometrial tumors (6%). Nonneoplastic lesions included amyloid-like material in the nasal septum (male and female 100%), otitis media (male 84%, female 79%), epididymal epithelial karyomegaly (88%), melanosis (high incidences in various tissues including brain, parathyroid, and spleen), membranoproliferative glomerulonephritis (male 52%, female 71%), hyalinosis with extracellular crystals in several tissues (respiratory tract, gall bladder, stomach), islet cell hyperplasia (male 45%, female 29%) and esophageal dilation (male 10%, female 6%). The B6; 129 mouse is a mouse with aging lesions similar to those in other mouse strains but with a characteristic common lymphoma.