Antibodies Against the Tom40 Subunit of the Translocase of the Outer Mitochondrial Membrane Complex and Cognitive Impairment in Alzheimer's Disease
Antibodies Against the Tom40 Subunit of the Translocase of the Outer Mitochondrial Membrane Complex and Cognitive Impairment in Alzheimer's Disease
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DOI：
10.3233/jad-2011-111343
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发表时间：
2012-01-01
影响因子：
4
通讯作者：
Inuzuka, Takashi
中科院分区：
文献类型：
--
作者：
Kimura, Akio;Sakurai, Takeo;Inuzuka, Takashi
最近的研究表明，微血管异常参与阿尔茨海默病的病理和进展。本研究的目的是检查阿尔茨海默病特异性脑微血管内皮细胞抗体的存在，并评估这些抗体与认知障碍的相关性。该研究包括阿尔茨海默病患者（年龄>= 60岁; 24名患者）、无神经系统疾病的对照受试者（年龄>= 60岁; 19名受试者）、多发性硬化症患者（所有年龄; 17名患者）和健康对照受试者（年龄>= 60岁; 17名患者）。
Recent studies suggest that microvascular abnormalities are involved in pathology and progression of Alzheimer's disease. The purpose of this study was to examine the presence of antibodies against cerebral microvascular endothelial cells specific for Alzheimer's disease, and to evaluate the association of these antibodies with cognitive impairment. The study included patients with Alzheimer's disease (age >= 60 years; 24 patients), control subjects without neurological diseases (age >= 60 years; 19 subjects), patients with multiple sclerosis (all ages; 17 patients), and healthy control subjects (age