Is Free/Total PSA Predictive of Pathological Stage and Gleason Score in Patients with Prostate Cancer and Serum PSA ≤10 ng/ml?
Is Free/Total PSA Predictive of Pathological Stage and Gleason Score in Patients with Prostate Cancer and Serum PSA ≤10 ng/ml?
复制标题
游离/总 PSA 能否预测血清 PSA ≤ 10 ng/ml 的前列腺癌患者的病理分期和格里森评分？
作者：
P. Pepe;P. Panella;F. Pietropaolo;M. Pennisi;R. Allegro;F. Aragona
前言：探讨游离前列腺特异性抗原百分比（%-fPSA）对前列腺癌（PCa）患者病理分期和Gleason评分的预测作用及血清PSA≤10 ng/ml。材料与方法：对100例接受根治性耻骨后前列腺切除术作为原发性前列腺癌治疗的总PSA≤10 ng/ml的患者，比较了器官限制性和非器官限制性前列腺癌患者以及Gleason评分≤/ bbb70的患者的%-fPSA水平。结果：32例为器官局限性前列腺癌，68例为局部晚期前列腺癌。中位数%-fPSA水平为15%；49例患者Gleasonscore <7, 40例等于7,11例等于7。Gleason评分≤/ bbb7的PCa中位数%-fPSA水平分别为14.5%、15.5%和15%。多元logistic回归分析未显示%-fPSA在器官局限性与非器官局限性前列腺癌中的相关性（p = 0.4991），也未显示Gleason评分<7与等于7 （p = 0.588）或>.7 （p = 0.547）之间的相关性。结论：对于血清PSA≤10 ng/ml的PCa患者，%-fPSA分界点似乎并不适用于术前分期。
Introduction: To evaluate whether percent free prostate-specific antigen (%-fPSA) could be predictive of pathological stage and Gleason score in patients with prostate cancer (PCa) and serum PSA of 10 ng/ml or less. Materials and Methods: In 100 patients with total PSA≤10 ng/ml who underwent radical retropubic prostatectomy as primary treatment of PCa, %-fPSA levels in organ-confined vs. non-organ-confined PCa and in patients with Gleason score ≤/>7 were compared. Results: 32 patients had an organ-confined and 68 a locally advanced PCa. Median %-fPSA level was 15%; Gleasonscore was <7 in 49 patients, equal to 7 in 40 and >7 in 11. Median %-fPSA levels in PCa with Gleason score ≤/>7 was 14, 15.5 and 15%, respectively. Multiple logistic regression analysis did not show any correlation between %-fPSA in organ-confined vs. non-organ-confined PCa (p = 0.4991) either between Gleason score <7 vs. equal to 7 (p = 0.588) or >7 (p = 0.547). Conclusions: %-fPSA cut-off does not seem to be useful for preoperative staging of patients with PCa and serum PSA ≤10 ng/ml.
使用人腺激肽释放酶 2 和前列腺特异性抗原结合临床分期和格里森分级，比较病理器官局限性临床阶段 T1c 前列腺癌的预测准确性。
DOI：
10.1097/01.ju.0000152618.38747.dd
发表时间：
2005
期刊：
The Journal of urology.
影响因子：
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作者：
Haese,Alexander;Vaisanen,Ville;Lilja,Hans;Kattan,MichaelW;Rittenhouse,HarryG;Pettersson,Kim;Chan,DanielW;Huland,Hartwig;Sokoll,LoriJ;Partin,AlanW
通讯作者：
Partin,AlanW