A pilot study for the effects of donepezil therapy on cerebral and optic nerve head blood flow, visual field defect in normal-tension glaucoma.
A pilot study for the effects of donepezil therapy on cerebral and optic nerve head blood flow, visual field defect in normal-tension glaucoma.
复制标题
多奈哌齐治疗对正常眼压青光眼脑和视神经乳头血流、视野缺损影响的初步研究。
DOI：
10.1089/jop.2009.0117
复制
发表时间：
2010
期刊：
影响因子：
--
通讯作者：
T. Ikeda
中科院分区：
文献类型：
--
作者：
Y. Yoshida;T. Sugiyama;K. Utsunomiya;Y. Ogura;T. Ikeda
目的
目的评价盐酸多奈哌齐（一种治疗阿尔茨海默病（AD）的药物）对具有AD样脑血流（CBF）减少的正常眼压性青光眼（NTG）患者的脑和视神经乳头（ONH）血流、视野缺损的影响。
方法
受试者为5例NTG患者，在（123）I-碘苯丙胺单光子发射计算机断层扫描（（123）I-IMP SPECT）时显示AD样CBF降低。在12个月期间，为每例患者开具盐酸多奈哌齐（5 mg/天）处方。治疗前和治疗期间每6个月测量眼压、Humphrey视野平均偏差、激光散斑血流图测定ONH血流量和（123）I-IMP SPECT测定局部脑血流量（rCBF）。
结果
MD、ONH血流和rCBF在治疗6个月后显著改善，尽管IOP没有显著变化。治疗12个月后，在任何测量参数中均未发现NTG发病率恶化。
结论
NTG患者口服盐酸多奈哌齐可预防视野缺损、ONH血流和颞叶、顶叶和后叶rCBF的恶化。这项初步研究表明，盐酸多奈哌齐可能会改善神经根性青光眼视神经病变。
PURPOSE
To evaluate the effect of donepezil hydrochloride, an agent for the treatment of Alzheimer's disease (AD), on the cerebral and optic nerve head (ONH) blood flow, visual field defect in normal-tension glaucoma (NTG) patients with decreased cerebral blood flow (CBF) that demonstrates an AD-like perfusion pattern.
METHODS
The subjects were 5 NTG patients who exhibited AD-like decreased CBF upon (123)I-iodoamphetamine single photon emission computed tomography ((123)I-IMP SPECT). Donepezil hydrochloride (5 mg/day) was prescribed for each patient during a period of 12 months. Intraocular pressure (IOP), mean deviation (MD) of the Humphrey visual field, ONH blood flow determined by a laser speckle flowgraphy, and regional CBF (rCBF) determined by (123)I-IMP SPECT were measured before and every 6 months during the treatment.
RESULTS
MD, ONH blood flow, and rCBF were improved significantly after 6 months of the treatment, although IOP did not change significantly. No deterioration of NTG morbidity was found in any of the measured parameters after 12 months of the treatment.
CONCLUSIONS
Oral administration of donepezil hydrochloride in NTG patients might prevent deterioration of visual field defect, ONH blood flow, and rCBF in the temporal, parietal, and posterior lobes. This pilot study suggested the possibility that donepezil hydrochloride might ameliorate glaucomatous optic neuropathy in NTG.