Prognostic Importance of Hyponatremia in Patients with Acute Pulmonary Embolism
Prognostic Importance of Hyponatremia in Patients with Acute Pulmonary Embolism
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DOI：
10.1164/rccm.201003-0481oc
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发表时间：
2010-11-01
影响因子：
24.7
通讯作者：
Aujesky, Drahomir
中科院分区：
文献类型：
--
作者：
Scherz, Nathalie;Labarere, Jose;Aujesky, Drahomir
基本原理：尽管与其他心肺疾病的不良结局相关，但低钠血症（神经激素激活的标志物）在急性肺栓塞（PE）患者中的预后价值尚不清楚。目的：研究低钠血症与PE住院患者的死亡率和再入院率之间的关系。方法：我们评估了宾夕法尼亚州185家医院（2000年1月至2002年11月）的13，728例初步诊断为PE的出院患者。我们使用随机截距logistic回归分析评估了就诊时血清钠水平与死亡率和30天内再入院之间的独立相关性，调整了患者（种族、保险、疾病严重程度、溶栓治疗的使用）和医院因素（地区、规模、教学状况）。低钠血症（钠
Rationale: Although associated with adverse outcomes in other cardiopulmonary conditions, the prognostic value of hyponatremia, a marker of neurohormonal activation, in patients with acute pulmonary embolism (PE) is unknown.Objectives: To examine the associations between hyponatremia and mortality and hospital readmission rates for patients hospitalized with PE.Methods: We evaluated 13,728 patient discharges with a primary diagnosis of PE from 185 hospitals in Pennsylvania (January 2000 to November 2002). We used random-intercept logistic regression to assess the independent association between serum sodium levels at the time of presentation and mortality and hospital readmission within 30 days, adjusting for patient (race, insurance, severity of illness, use of thrombolytic therapy) and hospital factors (region, size, teaching status).Measurements and Main Results. Hyponatremia (sodium