Cardiotoxicity of Antineoplastic Therapies and Applications of Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
Cardiotoxicity of Antineoplastic Therapies and Applications of Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
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作者：
Huang MF;Pang LK;Chen YH;Zhao R;Lee DF
近几十年来，在有效肿瘤药物研发的推动下，癌症治疗的方法有了显著发展。然而，许多癌症药物往往难以被身体，尤其是心血管系统耐受，会产生不良且有时是致命的副作用，从而抵消化疗的益处。化疗所致心脏毒性的普遍性和严重性，使得有必要对这一现象的机制和相关因素进行更深入的研究，并整合科研力量来制定缓解策略。近年来诱导多能干细胞（iPSCs）的出现对这些研究起到了推动作用，它使得诱导多能干细胞衍生的心肌细胞（iPSC - CMs）得以产生：这是一个基于人类、源自患者且具有基因多样性的平台，可应用于化疗所致心脏毒性及其他方面的研究。在综述了化疗所致心脏毒性以及相关化疗药物之后，我们探讨了iPSC - CMs在心脏毒性建模、药物筛选以及其他潜在应用中的使用。对iPSC - CM平台的改进，例如研发更接近成人的心肌细胞以及生物技术的不断进步，只会提高iPSC - CMs在基础科学和临床应用中的效用。
The therapeutic landscape for the treatment of cancer has evolved significantly in recent decades, aided by the development of effective oncology drugs. However, many cancer drugs are often poorly tolerated by the body and in particular the cardiovascular system, causing adverse and sometimes fatal side effects that negate the chemotherapeutic benefits. The prevalence and severity of chemotherapy-induced cardiotoxicity warrants a deeper investigation of the mechanisms and implicating factors in this phenomenon, and a consolidation of scientific efforts to develop mitigating strategies. Aiding these efforts is the emergence of induced pluripotent stem cells (iPSCs) in recent years, which has allowed for the generation of iPSC-derived cardiomyocytes (iPSC-CMs): a human-based, patient-derived, and genetically variable platform that can be applied to the study of chemotherapy-induced cardiotoxicity and beyond. After surveying chemotherapy-induced cardiotoxicity and the associated chemotherapeutic agents, we discuss the use of iPSC-CMs in cardiotoxicity modeling, drug screening, and other potential applications. Improvements to the iPSC-CM platform, such as the development of more adult-like cardiomyocytes and ongoing advances in biotechnology, will only enhance the utility of iPSC-CMs in both basic science and clinical applications.
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影响因子：
4.6
作者：
Christidi, Effimia;Huang, Haojun;Brunham, Liam R.
通讯作者：
Brunham, Liam R.
DOI：
10.2174/187152506775268785
发表时间：
2006-01-01
影响因子：
--
作者：
Alter, P.;Herzum, M.;Maisch, B.
通讯作者：
Maisch, B.
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
3
作者：
Fulbright JM;Egas-Bejar DE;Huh WW;Chandra J
通讯作者：
Chandra J
影响因子：
3.7
作者：
ElZarrad MK;Mukhopadhyay P;Mohan N;Hao E;Dokmanovic M;Hirsch DS;Shen Y;Pacher P;Wu WJ
通讯作者：
Wu WJ