Over-expression of HER-2 is associated with the stage in carcinomas of the urinary bladder.
Over-expression of HER-2 is associated with the stage in carcinomas of the urinary bladder.
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DOI：
10.3402/ljm.v7i0.14694
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Elzagheid A
中科院分区：
文献类型：
--
作者：
El Gehani K;Al-Kikhia L;Emaetig F;Syrjänen K;Al-Fituri O;Elzagheid A
人表皮生长因子受体-2(HER-2)在膀胱癌中过度表达的频率是所有人类恶性肿瘤中最高的之一。这种过度表达被认为在癌细胞的异常增殖中发挥了作用。对HER-2在膀胱癌中表达的研究显示出不同的结果。本研究的目的是评估HER-2蛋白在膀胱癌患者中的表达情况，并探讨其与肿瘤分级和分期的关系。对39例膀胱癌患者(女性6例，男性33例)进行HER-2过度表达的免疫组织化学检测。HER-2过表达在39例肿瘤中有23例(59%)，高级别癌高于低级别癌，但差异无统计学意义。HER-2的过度表达与肿瘤分期显著相关(p=0.011)。HER-2在移行细胞癌(TCC)和腺癌(AC)中的表达高于鳞癌(SCC)。患者年龄、性别与HER-2过度表达无关。HER-2在膀胱癌中的过度表达较为常见。了解HER-2基因状态有助于制定合理的膀胱癌治疗策略。
The frequency of over-expression of human epidermal growth factor receptor-2 (HER-2) in bladder cancer is one of the highest among all human malignancies. This over-expression is thought to play a role in aberrant proliferation of cancer cells. Studies on HER-2 expression in bladder carcinoma have shown heterogeneous results. The aim of the study was to evaluate the status of HER-2 protein expression in patients with invasive carcinomas of the urinary bladder as related to tumor grade and stage. Archival samples from 39 patients (6 women, 33 males) with urinary bladder cancer were analyzed for HER-2 over-expression, using immunohistochemistry with the HercepTest. HER-2 over-expression was observed in 23/39 tumors (59%) and was more frequent in high-grade than in low-grade carcinomas, but the difference was not statistically significant. A significant correlation was established between HER-2 over-expression and tumor stage (p=0.011). HER-2 expression was more frequent in transitional cell carcinomas (TCC) and adenocarcinomas (AC) as compared with squamous cell carcinoma (SCC). Patients’ age and sex were not related to HER-2 over-expression. Over-expression of HER-2 was frequent in carcinomas of the urinary bladder. Knowing the HER-2 status would be helpful in formulating a rational treatment strategy for patients with urinary bladder cancer.
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影响因子：
3.4
作者：
Gravalos, Cristina;Gomez-Martin, Carlos;Jimeno, Antonio
通讯作者：
Jimeno, Antonio
影响因子：
4.5
作者：
Gårdmark, T;Wester, K;Malmström, PU
通讯作者：
Malmström, PU
影响因子：
6.2
作者：
Gandour-Edwards, R;Lara, PN;DeVere-White, R
通讯作者：
DeVere-White, R
影响因子：
11.8
作者：
De Vita, F.;Giuliani, F.;Orditura, M.
通讯作者：
Orditura, M.
DOI：
10.1073/pnas.89.10.4285
发表时间：
1992-05-15
影响因子：
11.1
作者：
CARTER, P;PRESTA, L;SHEPARD, HM
通讯作者：
SHEPARD, HM