Temporal and morphological characteristics of high-frequency oscillations in an acute in vivo model of epilepsy.
Temporal and morphological characteristics of high-frequency oscillations in an acute in vivo model of epilepsy.
复制标题
急性体内癫痫模型高频振荡的时间和形态特征。
DOI：
10.1109/embc48229.2022.9871323
复制
发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Smith,RachelJune
中科院分区：
文献类型：
--
作者：
Zhai,SophiaR;Ehrens,Daniel;Li,Adam;Assaf,Fadi;Schiller,Yitzhak;Sarma,SrideviV;Smith,RachelJune
大约30%的癫痫患者对抗癫痫药物没有反应。手术切除癫痫发生区（癫痫发作发生和扩散的大脑区域）可能是这些患者的一种治疗方法，但由于各种临床因素，定位EZ具有挑战性。颅内脑电图（EEG）中的高频振荡（HFO）是一种很有希望的EZ生物标志物，但目前尚不清楚HFO率和HFO形态是否会随着病理脑网络的进化而发生调节，从而导致癫痫发作。为了解决这个问题，我们评估了HFO事件持续时间、HFO事件振幅和每分钟HFO发生率的时间演变。采用4AP啮齿动物癫痫模型对HFO事件进行量化，在两个不同的脑区诱导癫痫发作。我们发现，与海马模型相比，皮层模型的HFO事件持续时间和振幅显著增加。此外，在两种模型中，基线和临界前hfo之间的持续时间和幅度显著增加。另一方面，两种模式在振幅、持续时间或速率上均未表现出一致的增减趋势。临床相关性-我们在两种急性啮齿动物癫痫模型中评估了hfo的振幅、持续时间和发生率。从基线到孕前HFO形态的显著调节表明，这些特征可能是癫痫发生中涉及的病理组织的强有力的生物标志物。此外，在皮层和海马动物模型中观察到的HFO形态差异可能表明EZ的不同结构网络特征导致了这种调节。总之，我们发现HFO特征随着癫痫发作而显著调节，进一步强调了在ez定位研究中考虑HFO形态学的必要性。
Approximately 30% of patients with epilepsy do not respond to anti-epileptogenic drugs. Surgical removal of the epileptogenic zone (EZ), the brain regions where the seizures originate and spread, can be a possible therapy for these patients, but localizing the EZ is challenging due to a variety of clinical factors. High-frequency oscillations (HFOs) in intracranial electroencephalography (EEG) are a promising biomarker of the EZ, but it is currently unknown whether HFO rates and HFO morphology modulate as pathological brain networks evolve in a way that gives rise to seizures. To address this question, we assessed the temporal evolution of the duration of HFO events, amplitude of HFO events, and rates of HFOs per minute. HFO events were quantified using the 4AP in vivo rodent model of epilepsy, inducing seizures in two different brain areas. We found that the duration and amplitude of HFO events were significantly increased for the cortex model when compared to the hippocampus model. Additionally, the duration and amplitude increased significantly between baseline and pre-ictal HFOs in both models. On the other hand, the two models did not display a consistent increasing or decreasing trend in amplitude, duration or rate when comparing ictal and postictal intervals. Clinical Relevance- We assessed the amplitude, duration, and rate of HFOs in two acute in vivo rodent models of epilepsy. The significant modulation of HFO morphology from baseline to pre-ictal periods suggests that these features may be a robust biomarker for pathological tissue involved in epileptogenesis. Moreover, the differences in HFO morphology observed between cortex and hippocampus animal models possibly indicate that different structural network characteristics of the EZ cause this modulation. In all, we found that HFO features modulate significantly with the onset of seizures, further highlighting the need to consider of HFO morphology in EZ-localizing studies.