Astrocytes Control Synapse Formation, Function, and Elimination.
Astrocytes Control Synapse Formation, Function, and Elimination.
复制标题
DOI：
10.1101/cshperspect.a020370
复制
发表时间：
2015-02-06
影响因子：
7.2
通讯作者：
Eroglu C
中科院分区：
文献类型：
--
作者：
Chung WS;Allen NJ;Eroglu C
星形胶质细胞通过与突触的密切联系，可以监测和改变突触功能，从而主动控制成年大脑中的突触传递。除了它们在成年突触中的重要作用外，在过去的三十年中，许多重要的发现突出了星形胶质细胞在发育中的大脑中建立突触连接的重要性。在这篇文章中，我们将回顾星形胶质细胞控制突触的形成，功能和消除的关键发现。首先，我们将总结我们目前的结构和功能的了解星形胶质细胞在突触。然后，我们将讨论发育和成熟的星形胶质细胞指导突触形成、成熟和细化的细胞和分子机制。我们的目的是提供一个概述星形胶质细胞作为重要的球员在建立一个功能性神经系统。
Astrocytes, through their close associations with synapses, can monitor and alter synaptic function, thus actively controlling synaptic transmission in the adult brain. Besides their important role at adult synapses, in the last three decades a number of critical findings have highlighted the importance of astrocytes in the establishment of synaptic connectivity in the developing brain. In this article, we will review the key findings on astrocytic control of synapse formation, function, and elimination. First, we will summarize our current structural and functional understanding of astrocytes at the synapse. Then, we will discuss the cellular and molecular mechanisms through which developing and mature astrocytes instruct the formation, maturation, and refinement of synapses. Our aim is to provide an overview of astrocytes as important players in the establishment of a functional nervous system.