Acetylation polymorphism of caffeine in a Japanese population
Acetylation polymorphism of caffeine in a Japanese population
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日本人群中咖啡因的乙酰化多态性
DOI：
10.1038/clpt.1992.141
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发表时间：
1992
影响因子：
6.7
通讯作者：
A. Ebihara
中科院分区：
文献类型：
--
作者：
M. Hashiguchi;A. Ebihara
在140名无关的日本健康受试者中，通过测量口服咖啡因后尿液中咖啡因的两种主要代谢产物5-乙酰氨基-6-甲酰氨基-3-甲基尿嘧啶（AFMU）和1-甲基黄嘌呤（1X）的含量，确定了咖啡因N-乙酰化的频率分布。咖啡因的N-乙酰化能力似乎是多态的：15名受试者（10.7%）被表型为缓慢乙酰化者，而125名受试者（89.3%）被表型为快速乙酰化者。2小时尿液样本中AFMU的尿液摩尔排泄比（AFMU/1X）范围为0.03（缓慢乙酰化剂）至2.66（快速乙酰化剂）。本研究中慢乙酰化的频率与先前报道的日本人群中异烟肼和氨苯砜多态性相似。
The frequency distribution of N‐acetylation of caffeine was determined in 140 unrelated healthy Japanese subjects by measuring the amount of two main metabolites of caffeine, 5‐acetylamino‐6‐formylamino‐3‐methyluracil (AFMU) and 1‐methylxanthine (1X), in urine after an oral dose of caffeine. N‐Acetylation capacity for caffeine appeared to be polymorphic: 15 subjects (10.7%) were phenotyped as slow acetylators, whereas 125 subjects (89.3%) were phenotyped as rapid ones. The urinary molar excretion ratio of AFMU (AFMU/1X) in 2 hours‐urine samples ranged from 0.03 (slow acetylators) to 2.66 (rapid acetylators). The frequency of slow acetylators in this study was similar to that reported previously for the isoniazid and dapsone polymorphism in Japanese populations.