Dissociating state and item components of recognition memory using fMRI
Dissociating state and item components of recognition memory using fMRI
复制标题
DOI：
10.1006/nimg.2000.0664
复制
发表时间：
2001-01-01
期刊：
影响因子：
5.7
通讯作者：
Buckner, RL
中科院分区：
文献类型：
--
作者：
Donaldson, DI;Petersen, SE;Buckner, RL
认知功能，如记忆提取，涉及状态和项目相关过程的组合。与状态相关的过程在整个任务中持续（例如，与正在进行的目标相关联的“检索模式”），而与项目相关的过程是短暂的并且与个体刺激相关联（例如，与从记忆中恢复信息相关联的“检索成功”）。本研究采用了一种混合的“阻塞和事件相关”的实验设计，以确定在识别记忆任务中支持状态和项目相关过程的神经机制。受试者在固定和识别记忆（区分新旧单词）之间交替。重要的是，与事件相关的程序被嵌入到识别模块中，包括连续试验的抖动。这种设计确保了状态相关活动和项目相关活动的时间剖面不同，从而使它们可分离;如果没有这个过程，项目相关活动将求和以产生类似状态的响应。结果表明，三类大脑区域支持识别记忆，表现为：（1）主要是瞬时活动（包括内侧顶叶、外侧顶叶和左额叶前部皮层）反映与“提取成功”相关的项目相关处理，（2）主要是持续的活动（包括双侧海马旁皮质的活动减少）反映了与“检索模式”相关的状态相关处理，（3）同时发生的持续和短暂活动（包括左侧额中回、双侧额盖和内侧额回），反映了状态和项目相关处理的组合。目前的研究结果支持的想法，识别记忆任务是依赖于状态和项目相关的过程，具有可分离的神经相关识别功能磁共振成像的组合。此外，这里采用的混合“阻塞和事件相关”设计提供了一个通用的程序流程。用于分离状态和项目相关（C）2001年学术出版社。
Cognitive functions such as memory retrieval involve a combination of state- and item-related processes. State-related processes are sustained throughout a task (e.g., "retrieval mode" associated with ongoing goals), whereas item-related processes are transient and allied to individual stimuli (e.g., "retrieval success" associated with the recovery of information from memory). The present study employed a mixed "blocked and event-related" experimental design to identify neural mechanisms that support state- and item-related processes during a recognition memory task. Subjects alternated between blocks of fixation and recognition memory (discriminating between old and new words). Critically, event-related procedures were embedded within the recognition blocks, including the jittering of sequential trials. This design ensures that the temporal profiles of state- and item-related activity differ and consequently renders them separable; without this procedure item-related activity would summate to produce a state-like response. Results suggest three classes of brain region support recognition memory, exhibiting: (1) predominantly transient activity (including regions in medial parietal, lateral parietal, and anterior left frontal cortex) reflecting item-related processing associated with "retrieval success," (2) predominantly sustained activity (including decreased activity in bilateral parahippocampal cortex) reflecting state-related processing associated with "retrieval mode," (3) concurrent sustained and transient activity (including regions in left middle frontal gyrus, bilateral frontal operculum, and medial frontal gyrus), reflecting a combination of state- and item-related processing. The present findings support the idea that recognition memory tasks are dependent upon a combination of state- and item-related processes that have dissociable neural correlates identifiable using fMRI. Moreover, the mixed "blocked and event-related" design employed here provides a general procedure processes. for separating state- and item-related (C) 2001 Academic Press.