ALLERGIC PHENOTYPE - MANIFESTATION OF ALLERGIC BREAKTHROUGH AND IMBALANCE IN NORMAL DAMPING OF IGE ANTIBODY-PRODUCTION
ALLERGIC PHENOTYPE - MANIFESTATION OF ALLERGIC BREAKTHROUGH AND IMBALANCE IN NORMAL DAMPING OF IGE ANTIBODY-PRODUCTION
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DOI：
10.1111/j.1600-065x.1978.tb01461.x
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发表时间：
1978-01-01
影响因子：
8.7
通讯作者：
KATZ, DH
中科院分区：
文献类型：
--
作者：
KATZ, DH
与其他免疫球蛋白类一样，IgE类的抗体应答受复杂细胞和分子相互作用的精细连接网络调节（综述见Tada 1975，Ishizaka 1976，Katz 1977，1978）。然而，IgE系统在调节控制方面具有某些独特的方面，原因可能与IgE系统本身的生物重要性有关。例如，我们认为IgE抗体系统对某些攻击性外源性抗原，特别是那些通过粘膜上皮和上皮表面衬里（如呼吸道和胃肠道和皮肤）进入的抗原起着重要的防御作用。这种防御作用主要是由于IgE分子的特性--与其他免疫球蛋白分子不同--特异性和强烈地结合到组织固定的肥大细胞和循环嗜碱性粒细胞的表面膜上，这些细胞在其表面上表达IgE Fc部分决定簇的特异性受体。由于这两种细胞类型都具有大量的药理学活性介质，并且由于它们的IgE分子的Fc受体不基于它们的抗原特异性区分这些分子，因此在该系统内存在巨大的扩增机制，用于允许相对少量的分子发挥所需的生物学效应。似乎IgE抗体产生的总体调节控制已经被定制，
Antibody responses of the IgE class are, like other immxinoglobulin classes, regulated by a finely-txined network of complex cellular and molecular interactions (reviewed in Tada 1975, Ishizaka 1976, Katz 1977, 1978). The IgE system, however, has certain unique aspects to it in terms of regulatory controls for reasons that probably pertain to the biological importance of the IgE system itself. We believe, for example, that the IgE antibody system plays an important defense role against certain offending exogenous antigens, particularly those which gain access through mucoepithelial and epithelial surface linings such as the respiratory and gastrointestinal tract and skin. This defense role is performed predominantly as a consequence of the property of IgE molecules-unlike other immunoglobulin molecules-to bind specifically and avidly to the surface membranes of tissue-fixed mast cells and circulating basophils which express on their surfaces specific receptors for the determinants on the Fc portion of IgE. Since both of these cell types possess abundant quantities of pharmacologically-active mediators, and since their Fc receptors for IgE molecules do not discriminate such molecules on the basis of their antigen specificity, an enormous amplification mechanism exists within this system for permitting relatively small numbers of molecules to exert the desired biological effect Hence, it seems that the overall regulatory control of IgE antibody production has been tailored to