Low baseline pCO2 predicts poorer outcome from behavioral treatment: Evidence from a mixed anxiety disorders sample
Low baseline pCO2 predicts poorer outcome from behavioral treatment: Evidence from a mixed anxiety disorders sample
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DOI：
10.1016/j.psychres.2014.06.003
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发表时间：
2014-10-30
影响因子：
11.3
通讯作者：
Craske, Michelle G.
中科院分区：
文献类型：
--
作者：
Davies, Carolyn D.;Craske, Michelle G.
低水平的二氧化碳潮气末分压（pCO（2）），从呼出的空气中测量的二氧化碳量通常在焦虑症患者中发现，但尚未被视为焦虑症治疗结果的预测因素。目前的研究检查了治疗前基线pCO（2）作为焦虑症认知行为治疗（CBT）和接受与承诺治疗（ACT）结果的预测因子。61名患有精神疾病诊断和统计手册（DSM-IV）定义的主要焦虑症诊断的个体完成了12次CBT或ACT。在进入治疗前测量基线pCO（2）。在治疗前、治疗后以及从基线开始的6个月和12个月随访时，对自我报告的焦虑症状和生活质量进行评估。基线pCO（2）较低与随访时间点的焦虑症状较高和生活质量较低相关，高于和超过基线症状严重程度。这些结果表明，低基线pCO（2）预测CBT和ACT治疗焦虑的结果较差，可能需要直接针对呼吸失调的治疗。(C)2014爱思唯尔爱尔兰有限公司版权所有。
Low levels of end-tidal partial pressure of carbon dioxide (pCO(2)) the amount of carbon dioxide measured from expired air are commonly found in individuals with anxiety disorders but have not been examined as predictors of outcome from anxiety treatment. The current study examined pretreatment baseline pCO(2) as a predictor of outcome from cognitive behavioral therapy (CBT) and acceptance and commitment therapy (ACT) for anxiety disorders. Sixty-one individuals with a Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) defined principal anxiety disorder diagnosis completed 12 sessions of either CBT or ACT. Baseline pCO(2) was measured prior to entering treatment. Self-reported anxiety symptoms and quality of life were assessed at pre-treatment, post-treatment, and 6- and 12-month follow-up from baseline. Low baseline pCO(2) was associated with higher anxiety symptoms and lower quality of life across follow-up timepoints, above and beyond baseline symptom severity. These results suggest that low baseline pCO(2) predicts poorer outcome from CBT and ACT for anxiety and may warrant treatment that directly addresses respiratory dysregulation. (C) 2014 Elsevier Ireland Ltd. All rights reserved.