Loss of β-catenin is associated with poor survival in ovarian carcinomas
Loss of β-catenin is associated with poor survival in ovarian carcinomas
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DOI：
10.1097/01.pgp.0000139711.22158.14
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发表时间：
2004-10-01
影响因子：
2.4
通讯作者：
Lopes, CS
中科院分区：
文献类型：
--
作者：
Faleiro-Rodrigues, C;Macedo-Pinto, I;Lopes, CS
连环蛋白（α-、β-和γ-）是与上皮钙粘蛋白分子的保守尾部结合的细胞质蛋白。上皮钙粘蛋白在粘附连接处的功能依赖于有效的细胞间粘附的连环蛋白。在几种人类癌症中已经报道了连环蛋白表达的缺失，并且与肿瘤分化差、晚期肿瘤阶段和患者存活率差相关。在这项研究中，我们调查了104例原发性卵巢癌患者的α-，β-和γ-连环蛋白免疫表达与临床病理特征的临床相关性，并作为疾病复发和预后的预测因子。研究的临床病理参数包括国际妇产科联盟（FIGO）分期、组织学类型、肿瘤分化程度、腹膜转移。术后残留肿瘤、肿瘤浆膜表面完整性、腹膜细胞学检查和淋巴/血管浸润。在22例（21%）、15例（14%）和23例（22%）病例中分别观察到α-连环蛋白、β-连环蛋白和γ-连环蛋白的阴性免疫反应性。α-连环蛋白和γ-连环蛋白的免疫反应性与所测试的任何临床病理学参数均不相关。β-连环蛋白的免疫表达模式与组织学类型相关（p = 0.026），单变量分析中总生存率较差（p = 0.022）。在浆液性癌组中，β-连环蛋白免疫表达与总生存率显著相关。β-连环蛋白阴性浆液性癌患者的总体生存率低于β-连环蛋白阳性浆液性癌患者（p = 0.013）。在多变量分析中，β-连环蛋白的阴性表达（p = 0.003）和残留肿瘤的存在（p = 0.019）是预测总生存率较差的两个最重要的独立预后因素。总之，β-连环蛋白在浆液性癌中的阴性免疫反应性和残留肿瘤的存在似乎是选择可能具有不利过程的患者的有用标志物。
The catenins (alpha-, beta- and gamma-) are cytoplasmic proteins that bind to the conserved tail of the epithelial cadherin molecule. The function of epithelial cadherin at the adherens junctions is dependent on the catenins for efficient cell-to-cell adhesion. Loss of catenin expression has been reported in several human cancers and associated with poor tumor differentiation, advanced tumor stage, and poor patient survival. In this study, we investigated the clinical relevance of alpha-, beta-, and gamma-catenin immunoexpression in 104 cases of primary ovarian carcinoma with respect to clinicopathological features and as predictors of disease recurrence and prognosis. The clinicopathological parameters studied were International Federation of Gynaecology and Obstetrics (FIGO) stage, histological type, tumor differentiation, peritoneal metastases. residual postoperative tumor, integrity of the tumor's serosal surface, peritoneal cytology, and lymphatic/vascular invasion. Negative immunoreactivity of alpha-catenin, beta-catenin, and gamma-catenin was observed in 22 (21%), 15 (14%) and 23 (22%) cases, respectively. Immunoreactivity of alpha-catenin and gamma-catenin did not correlate with any of the clinicopathological parameters tested. The immunoexpression pattern of beta-catenin correlated with histological type (p = 0.026) and with a poorer overall survival in univariate analyses (p = 0.022). In the group of serous carcinomas, beta-catenin-immunoexpression associated significantly with overall survival. Patients With beta-catenin-negative serous carcinomas had a poorer overall survival than patients with beta-catenin-positive serous carcinomas (p = 0.013). In the multivariate analysis, negative expression of beta-catenin (p = 0.003) and the presence of residual tumor (p = 0.019) were the two most important independent prognostic factors predicting poorer overall survival. In conclusion, negative immunoreactivity of beta-catenin in serous carcinomas and the presence of residual tumor seem to be useful markers in selecting patients likely to have an unfavorable course.