Dopaminergic Neurotransmission in the Nucleus Accumbens Modulates Social Play Behavior in Rats
Dopaminergic Neurotransmission in the Nucleus Accumbens Modulates Social Play Behavior in Rats
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DOI：
10.1038/npp.2016.22
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发表时间：
2016-08-01
影响因子：
7.6
通讯作者：
Trezza, Viviana
中科院分区：
文献类型：
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作者：
Manduca, Antonia;Servadio, Michela;Trezza, Viviana
社会游戏行为是年轻哺乳动物表现出的一种高度奖励的社会互动形式。社会游戏对神经行为发育很重要，并且已经发现在几种发育性精神障碍中受到损害。与社交游戏的奖励特性一致，我们以前已经确定了神经核（NAc）作为内源性大麻素和阿片类药物调节这种行为的重要作用部位。NAc多巴胺在奖励过程的某些组成部分中具有众所周知的作用，例如激励动机。然而，它对社会互动的积极情感方面的贡献不太清楚。因此，我们研究的作用，多巴胺能神经传递的NAc在大鼠的社会游戏行为。我们发现，NAc内注入多巴胺受体阻滞剂/再摄取抑制剂安非他明增加了依赖于D1和D2多巴胺受体激活的社交游戏行为。这种社交游戏行为的增加被多巴胺受体激动剂阿扑吗啡的NAc内输注所模仿，但不是多巴胺再摄取抑制剂GBR-12909。阻断D1或D2 NAc多巴胺受体减少了动物的社交游戏，这些动物在测试前由于较长的社会隔离而具有高度的游戏动机。最后，NAc多巴胺受体的阻断阻止了内源性大麻素和阿片受体刺激的玩耍增强作用。这些研究结果表明，NAc多巴胺能神经传递在社会发挥重要的调节作用。因此，中脑边缘多巴胺通路中的功能活动在适应性社会发展中起着重要作用，而NAc多巴胺功能异常可能是在发育性精神障碍如自闭症、注意缺陷多动障碍或早发性精神分裂症中观察到的社会障碍的基础。
Social play behavior is a highly rewarding form of social interaction displayed by young mammals. Social play is important for neurobehavioral development and it has been found to be impaired in several developmental psychiatric disorders. In line with the rewarding properties of social play, we have previously identified the nucleus accumbens (NAc) as an important site of action for endocannabinoid and opioid modulation of this behavior. NAc dopamine has a well-known role in certain components of reward processes, such as incentive motivation. However, its contribution to the positive emotional aspects of social interactions is less clear. Therefore, we investigated the role of dopaminergic neurotransmission in the NAc in social play behavior in rats. We found that intra-NAc infusion of the dopamine releaser/reuptake inhibitor amphetamine increased social play behavior that was dependent on activation of both D1 and D2 dopamine receptors. This increase in social play behavior was mimicked by intra-NAc infusion of the dopamine receptor agonist apomorphine, but not of the dopamine reuptake inhibitor GBR-12909. Blockade of either D1 or D2 NAc dopamine receptors reduced social play in animals highly motivated to play as a result of longer social isolation before testing. Last, blockade of NAc dopamine receptors prevented the play-enhancing effects of endocannabinoid and opioid receptor stimulation. These findings demonstrate an important modulatory role of NAc dopaminergic neurotransmission in social play. Thus, functional activity in the mesolimbic dopamine pathway plays an important role in adaptive social development, whereas abnormal NAc dopamine function may underlie the social impairments observed in developmental psychiatric disorders such as autism, attention deficit hyperactivity disorder or early-onset schizophrenia.