Towards an understanding of the role of intrinsic protein disorder on plant adaptation to environmental challenges
Towards an understanding of the role of intrinsic protein disorder on plant adaptation to environmental challenges
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DOI：
10.1007/s12192-020-01162-5
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发表时间：
2020-09-09
影响因子：
3.8
通讯作者：
Carlos Rodriguez-Zapata, Luis
中科院分区：
文献类型：
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作者：
Alejandro Zamora-Briseno, Jesus;Pereira-Santana, Alejandro;Carlos Rodriguez-Zapata, Luis
内在蛋白质无序是一个有趣的结构特征，其中功能齐全的蛋白质在溶液中缺乏三维结构。在这项工作中，我们估计了 96 种植物蛋白质组（包括单子叶植物和双子叶植物）中内在蛋白质紊乱的相对含量。在这项分析中，我们发现这些主要进化枝之间内在蛋白质无序的相对丰度存在差异。单子叶植物的相对紊乱程度高于双子叶植物。反过来，内在蛋白质无序程度与蛋白质长度之间存在反比关系，越小的蛋白质越无序。氨基酸的相对丰度取决于内在的紊乱，并且在进化枝之间也存在差异。在细胞核内，本质上无序的蛋白质比有序的蛋白质更丰富。本质上无序的蛋白质专门负责调节功能、核酸结合、RNA 加工以及对环境刺激的反应。讨论了这对植物对其环境的反应的影响。
Intrinsic protein disorder is an interesting structural feature where fully functional proteins lack a three-dimensional structure in solution. In this work, we estimated the relative content of intrinsic protein disorder in 96 plant proteomes including monocots and eudicots. In this analysis, we found variation in the relative abundance of intrinsic protein disorder among these major clades; the relative level of disorder is higher in monocots than eudicots. In turn, there is an inverse relationship between the degree of intrinsic protein disorder and protein length, with smaller proteins being more disordered. The relative abundance of amino acids depends on intrinsic disorder and also varies among clades. Within the nucleus, intrinsically disordered proteins are more abundant than ordered proteins. Intrinsically disordered proteins are specialized in regulatory functions, nucleic acid binding, RNA processing, and in response to environmental stimuli. The implications of this on plants' responses to their environment are discussed.