The compensatory anti-inflammatory cytokine interleukin 10 response in pediatric sepsis-induced multiple organ failure
The compensatory anti-inflammatory cytokine interleukin 10 response in pediatric sepsis-induced multiple organ failure
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DOI：
10.1378/chest.113.6.1625
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发表时间：
1998-06-01
期刊：
影响因子：
9.6
通讯作者：
Janosky, J
中科院分区：
文献类型：
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作者：
Doughty, L;Carcillo, JA;Janosky, J
设计：前瞻性研究。地点：大学儿科ICU。患者：连续53例脓毒症患儿和15例无脓毒症危重患儿，干预：血浆IL-10、IL-6、对53例脓毒症患儿在感染后第1~3天和对照组患儿在感染后第1天和第3天分别测定血浆中亚硝酸盐+硝酸盐(NO稳定的终产物)水平和器官衰竭指数(OFI)。17例败血症患儿在感染后第1天用外源性人IL-10或中和IL-10抗体对全血培养上清中IL-6水平的影响。P
Study objectives: To determine the circulating anti-inflammatory cytokine interleukin 10 (IL-10) response during the development of sepsis-induced multiple organ failure in children.Design: Prospective study.Setting: University pediatric ICU.Patients: Fifty-three consecutive children with sepsis and 15 critically ill children without sepsis,Interventions: Plasma IL-10, interleukin 6 (IL-6), and nitrite+nitrate (stable end products of nitric oxide) levels and an organ failure index (OFI indicating the number of failing organ systems) were determined in 53 children on days 1 to 3 of sepsis and in control children on day 1. The effect of exogenous human IL-10 or neutralizing IL-10 antibody on supernatant IL-6 levels in ex vivo whole blood culture from 17 children on day 1 of sepsis,Measurements ana results: Children with three or more organ failures had higher plasma IL-10 levels than children with less than 3 organ failures (days 1 and 3; p